4mgz
From Proteopedia
(Difference between revisions)
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==Selective activation of Epac1 and Epac2== | ==Selective activation of Epac1 and Epac2== | ||
| - | <StructureSection load='4mgz' size='340' side='right' caption='[[4mgz]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='4mgz' size='340' side='right'caption='[[4mgz]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4mgz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MGZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4mgz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MGZ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HR6:(2S,4AR,6R,7R,7AS)-6-[6-AMINO-8-(BENZYLSULFANYL)-9H-PURIN-9-YL]-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HR6:(2S,4AR,6R,7R,7AS)-6-[6-AMINO-8-(BENZYLSULFANYL)-9H-PURIN-9-YL]-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2byv|2byv]], [[3cf6|3cf6]], [[4mgi|4mgi]], [[4mgk|4mgk]], [[4mgy|4mgy]], [[4mh0|4mh0]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2byv|2byv]], [[3cf6|3cf6]], [[4mgi|4mgi]], [[4mgk|4mgk]], [[4mgy|4mgy]], [[4mh0|4mh0]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rapgef4, Cgef2, Epac2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), RAP1B, OK/SW-cl.11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgz OCA], [http://pdbe.org/4mgz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mgz RCSB], [http://www.ebi.ac.uk/pdbsum/4mgz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mgz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgz OCA], [http://pdbe.org/4mgz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mgz RCSB], [http://www.ebi.ac.uk/pdbsum/4mgz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mgz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE]] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref> [[http://www.uniprot.org/uniprot/RAP1B_HUMAN RAP1B_HUMAN]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.<ref>PMID:20332120</ref> <ref>PMID:18660803</ref> | [[http://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE]] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref> [[http://www.uniprot.org/uniprot/RAP1B_HUMAN RAP1B_HUMAN]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.<ref>PMID:20332120</ref> <ref>PMID:18660803</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[GTP-binding protein|GTP-binding protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Rehmann, H]] | [[Category: Rehmann, H]] | ||
[[Category: Guanine nucleotide exchange factor]] | [[Category: Guanine nucleotide exchange factor]] | ||
[[Category: Nucleotide binding]] | [[Category: Nucleotide binding]] | ||
[[Category: Signaling protein-gtp-binding protein complex]] | [[Category: Signaling protein-gtp-binding protein complex]] | ||
Revision as of 08:31, 10 April 2019
Selective activation of Epac1 and Epac2
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