4n9u
From Proteopedia
(Difference between revisions)
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==The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | ==The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | ||
| - | <StructureSection load='4n9u' size='340' side='right' caption='[[4n9u]], [[Resolution|resolution]] 2.11Å' scene=''> | + | <StructureSection load='4n9u' size='340' side='right'caption='[[4n9u]], [[Resolution|resolution]] 2.11Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4n9u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9U FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4n9u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9U FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kpd|4kpd]], [[4kpj|4kpj]], [[4kq5|4kq5]], [[4kqs|4kqs]], [[4kqu|4kqu]], [[1yq7|1yq7]], [[4nua|4nua]], [[4ng6|4ng6]], [[4nke|4nke]], [[4nkf|4nkf]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kpd|4kpd]], [[4kpj|4kpj]], [[4kq5|4kq5]], [[4kqs|4kqs]], [[4kqu|4kqu]], [[1yq7|1yq7]], [[4nua|4nua]], [[4ng6|4ng6]], [[4nke|4nke]], [[4nkf|4nkf]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9u OCA], [http://pdbe.org/4n9u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n9u RCSB], [http://www.ebi.ac.uk/pdbsum/4n9u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9u ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9u OCA], [http://pdbe.org/4n9u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n9u RCSB], [http://www.ebi.ac.uk/pdbsum/4n9u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Barnett, B L]] | [[Category: Barnett, B L]] | ||
[[Category: Dunford, J E]] | [[Category: Dunford, J E]] | ||
Revision as of 09:04, 10 April 2019
The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
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Categories: Human | Large Structures | Barnett, B L | Dunford, J E | Ebetino, F H | Evdokimov, A | Kavanagh, K L | Kwaasi, A A | Muniz, J R.C | Oppermann, U | Pilka, E | Russell, R G.G | Tsoumpra, M K | Walter, R L | Alpha-helical prenyltransferase fold | Dimethylallyl pyrophosphate | Isopentenyl pyrophosphate | Isoprene biosynthesis | Lipid synthesis | Steroid biosynthesis | Transferase
