Blue copper oxidase CueO

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== Function ==
== Function ==
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'''Blue copper oxidase CueO''' (CueO) is an ''E. coli'' enzyme which catalyzes the conversion of Cu+1 to Cu+2 resulting in the detoxification of copper by the prevention of its uptake into the cytoplasm.<ref>PMID:11527384</ref>
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'''Blue copper oxidase CueO''' (CueO) or '''laccase CueO''' is an ''E. coli'' enzyme which catalyzes the conversion of Cu+1 to Cu+2 resulting in the detoxification of copper by the prevention of its uptake into the cytoplasm.<ref>PMID:11527384</ref>
== Relevance ==
== Relevance ==

Revision as of 10:20, 14 April 2019

Structure of E. coli blue copper oxidase CueO complex with two Cu+2 ions (orange), Cu-O-Cu and citrate (PDB code 2fqf).

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3D structures of blue copper oxidase CueO

Updated on 14-April-2019

3nsf – EcCueO – Escherichia coli
3nt0 – EcCueO (mutant) + Cu+1
3od3, 3pav, 4e9q, 4e9r, 4e9s, 4e9t, 4ef3, 4ner, 5b7e, 5b7f, 5b7m – EcCueO + Cu+2
3nsc, 3nsd, 3uaa, 3uab, 3uac, 3uad, 3uae, 4hak, 4hal – EcCueO (mutant) + Cu+2
3qqx – EcCueO (mutant) + Cu+2 + Cu+1
1n68 – EcCueO + Cu+2 + Cu-Cl-Cu
1pf3 – EcCueO (mutant) + Cu+2 + Cu-Cl-Cu
2fqd, 2fqe, 2fqf, 2fqg, 3pau – EcCueO + Cu+2 + Cu-O-Cu
2yxv, 2yxw, 3nsy – EcCueO (mutant) + Cu+2 + Cu-O-Cu



References

  1. Grass G, Rensing C. CueO is a multi-copper oxidase that confers copper tolerance in Escherichia coli. Biochem Biophys Res Commun. 2001 Sep 7;286(5):902-8. PMID:11527384 doi:http://dx.doi.org/10.1006/bbrc.2001.5474
  2. Li X, Wei Z, Zhang M, Peng X, Yu G, Teng M, Gong W. Crystal structures of E. coli laccase CueO at different copper concentrations. Biochem Biophys Res Commun. 2007 Mar 2;354(1):21-6. Epub 2006 Dec 22. PMID:17217912 doi:10.1016/j.bbrc.2006.12.116

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