6qjl
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group P21== | |
| - | + | <StructureSection load='6qjl' size='340' side='right'caption='[[6qjl]], [[Resolution|resolution]] 1.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qjl]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5oii 5oii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5oii|5oii]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qjl OCA], [http://pdbe.org/6qjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qjl RCSB], [http://www.ebi.ac.uk/pdbsum/6qjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qjl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Camara-Artigas, A]] | [[Category: Camara-Artigas, A]] | ||
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 05:44, 17 April 2019
Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group P21
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