6qjn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group I4122== | |
| - | + | <StructureSection load='6qjn' size='340' side='right'caption='[[6qjn]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qjn]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5oij 5oij]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qjn OCA], [http://pdbe.org/6qjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qjn RCSB], [http://www.ebi.ac.uk/pdbsum/6qjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qjn ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Camara-Artigas, A]] | [[Category: Camara-Artigas, A]] | ||
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 05:44, 17 April 2019
Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group I4122
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