6ogn
From Proteopedia
(Difference between revisions)
m (Protected "6ogn" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse protein arginine methyltransferase 7 in complex with SGC8158 chemical probe== | |
| - | + | <StructureSection load='6ogn' size='340' side='right'caption='[[6ogn]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ogn]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6npg 6npg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OGN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MJ7:5-S-(4-{[(4-chloro[1,1-biphenyl]-3-yl)methyl]amino}butyl)-5-thioadenosine'>MJ7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_III_protein_arginine_methyltransferase Type III protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.321 2.1.1.321] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ogn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ogn OCA], [http://pdbe.org/6ogn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ogn RCSB], [http://www.ebi.ac.uk/pdbsum/6ogn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ogn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ANM7_MOUSE ANM7_MOUSE]] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity).<ref>PMID:17048991</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Type III protein arginine methyltransferase]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Dong, A]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Halabelian, L]] | ||
[[Category: Hutchinson, A]] | [[Category: Hutchinson, A]] | ||
| - | [[Category: | + | [[Category: Li, Y]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
[[Category: Seitova, A]] | [[Category: Seitova, A]] | ||
| - | [[Category: Dong, A]] | ||
| - | [[Category: Structural Genomics Consortium (Sgc)]] | ||
| - | [[Category: Li, Y]] | ||
| - | [[Category: Halabelian, L]] | ||
[[Category: Zeng, H]] | [[Category: Zeng, H]] | ||
| - | [[Category: | + | [[Category: Chemical probe]] |
| + | [[Category: Prmt7]] | ||
| + | [[Category: Sgc8158]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 05:44, 17 April 2019
Crystal structure of mouse protein arginine methyltransferase 7 in complex with SGC8158 chemical probe
| |||||||||||
