6cz6

Structural highlights

Function

[PRPR_MYCTU] Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route) (PubMed:22916289, PubMed:24705740). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate (PubMed:22365605). PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor (PubMed:22916289). During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA, which encodes the DnaA initiator protein responsible for initiating chromosomal replication (PubMed:24705740). It is possibly involved in the regulation of genes responsible for controlling cholesterol utilization (PubMed:22365605).^{[1] [2] [3]}

References

1. ↑ Griffin JE, Pandey AK, Gilmore SA, Mizrahi V, McKinney JD, Bertozzi CR, Sassetti CM. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Chem Biol. 2012 Feb 24;19(2):218-27. doi: 10.1016/j.chembiol.2011.12.016. PMID:22365605 doi:http://dx.doi.org/10.1016/j.chembiol.2011.12.016
2. ↑ Masiewicz P, Brzostek A, Wolanski M, Dziadek J, Zakrzewska-Czerwinska J. A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis. PLoS One. 2012;7(8):e43651. doi: 10.1371/journal.pone.0043651. Epub 2012 Aug 16. PMID:22916289 doi:http://dx.doi.org/10.1371/journal.pone.0043651
3. ↑ Masiewicz P, Wolanski M, Brzostek A, Dziadek J, Zakrzewska-Czerwinska J. Propionate represses the dnaA gene via the methylcitrate pathway-regulating transcription factor, PrpR, in Mycobacterium tuberculosis. Antonie Van Leeuwenhoek. 2014 May;105(5):951-9. doi: 10.1007/s10482-014-0153-0., Epub 2014 Apr 5. PMID:24705740 doi:http://dx.doi.org/10.1007/s10482-014-0153-0