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6d2s

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'''Unreleased structure'''
 
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The entry 6d2s is ON HOLD until Paper Publication
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==Mycobacterium tuberculosis transcriptional regulator==
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<StructureSection load='6d2s' size='340' side='right'caption='[[6d2s]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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Authors: Tang, S., Sacchettini, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6d2s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D2S FirstGlance]. <br>
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Description: Mycobacterium tuberculosis transcriptional regulator
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cz6|6cz6]], [[6cyy|6cyy]], [[6cyj|6cyj]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d2s OCA], [http://pdbe.org/6d2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d2s RCSB], [http://www.ebi.ac.uk/pdbsum/6d2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d2s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PRPR_MYCTU PRPR_MYCTU]] Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route) (PubMed:22916289, PubMed:24705740). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate (PubMed:22365605). PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor (PubMed:22916289). During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA, which encodes the DnaA initiator protein responsible for initiating chromosomal replication (PubMed:24705740). It is possibly involved in the regulation of genes responsible for controlling cholesterol utilization (PubMed:22365605).<ref>PMID:22365605</ref> <ref>PMID:22916289</ref> <ref>PMID:24705740</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Sacchettini, J]]
[[Category: Tang, S]]
[[Category: Tang, S]]
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[[Category: Sacchettini, J]]
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[[Category: Transcription]]
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[[Category: Transcriptional regulator]]

Revision as of 05:53, 17 April 2019

Mycobacterium tuberculosis transcriptional regulator

PDB ID 6d2s

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