6d48
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cell Surface Receptor== | |
| - | + | <StructureSection load='6d48' size='340' side='right'caption='[[6d48]], [[Resolution|resolution]] 1.78Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d48]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D48 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d48 OCA], [http://pdbe.org/6d48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d48 RCSB], [http://www.ebi.ac.uk/pdbsum/6d48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d48 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD33_HUMAN CD33_HUMAN]] Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).<ref>PMID:10556798</ref> <ref>PMID:11320212</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hermans, S J]] | ||
| + | [[Category: Miles, L A]] | ||
| + | [[Category: Parker, M W]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Sialic acid binding]] | ||
| + | [[Category: Siglec]] | ||
| + | [[Category: Transmembrane]] | ||
Revision as of 05:53, 17 April 2019
Cell Surface Receptor
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