6g8k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==14-3-3sigma in complex with a S131beta3S mutated YAP pS127 phosphopeptide== | |
| - | + | <StructureSection load='6g8k' size='340' side='right'caption='[[6g8k]], [[Resolution|resolution]] 1.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g8k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G8K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BSE:BETA-3-SERINE'>BSE</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g8i|6g8i]], [[6g6x|6g6x]], [[6g8j|6g8j]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g8k OCA], [http://pdbe.org/6g8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g8k RCSB], [http://www.ebi.ac.uk/pdbsum/6g8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g8k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Andrei, S A]] | ||
| + | [[Category: Brunsveld, L]] | ||
| + | [[Category: Milroy, L G]] | ||
| + | [[Category: Ottmann, C]] | ||
| + | [[Category: Thijssen, V]] | ||
| + | [[Category: Beta amino acid]] | ||
| + | [[Category: Hippo pathway]] | ||
| + | [[Category: Oncoprotein]] | ||
| + | [[Category: Yap/taz]] | ||
Revision as of 05:56, 17 April 2019
14-3-3sigma in complex with a S131beta3S mutated YAP pS127 phosphopeptide
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