5i3o
From Proteopedia
(Difference between revisions)
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==Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor== | ==Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor== | ||
| - | <StructureSection load='5i3o' size='340' side='right' caption='[[5i3o]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='5i3o' size='340' side='right'caption='[[5i3o]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5i3o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3O FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5i3o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3O FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDV:N-(6-{3-[(DIMETHYLSULFAMOYL)AMINO]PHENYL}-1H-INDAZOL-3-YL)CYCLOPROPANECARBOXAMIDE'>IDV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDV:N-(6-{3-[(DIMETHYLSULFAMOYL)AMINO]PHENYL}-1H-INDAZOL-3-YL)CYCLOPROPANECARBOXAMIDE'>IDV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4w9w|4w9w]], [[4w9x|4w9x]], [[5i3r|5i3r]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4w9w|4w9w]], [[4w9x|4w9x]], [[5i3r|5i3r]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BMP2K, BIKE, HRIHFB2017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3o OCA], [http://pdbe.org/5i3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3o RCSB], [http://www.ebi.ac.uk/pdbsum/5i3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3o ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3o OCA], [http://pdbe.org/5i3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3o RCSB], [http://www.ebi.ac.uk/pdbsum/5i3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3o ProSAT]</span></td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
Revision as of 06:22, 17 April 2019
Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor
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Categories: Human | Large Structures | Non-specific serine/threonine protein kinase | Arrowsmith, C H | Arruda, P | Axtman, A | Bountra, C | Counago, R M | Drewry, D | Edwards, A M | Elkins, J M | Gileadi, O | Krojer, T | Structural genomic | Savitsky, P | Sorrell, F J | Wells, C | Willson, T M | Zhang, C | Zuercher, W | Protein kinase domain | Sgc | Transferase | Transferase-transferase inhibitor complex
