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5i3r

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==Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor==
==Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor==
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<StructureSection load='5i3r' size='340' side='right' caption='[[5i3r]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='5i3r' size='340' side='right'caption='[[5i3r]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i3r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i3r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I3R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDK:N-[6-(3-{[(CYCLOPROPYLMETHYL)SULFONYL]AMINO}PHENYL)-1H-INDAZOL-3-YL]CYCLOPROPANECARBOXAMIDE'>IDK</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDK:N-[6-(3-{[(CYCLOPROPYLMETHYL)SULFONYL]AMINO}PHENYL)-1H-INDAZOL-3-YL]CYCLOPROPANECARBOXAMIDE'>IDK</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i3o|5i3o]], [[4w9w|4w9w]], [[4w9x|4w9x]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i3o|5i3o]], [[4w9w|4w9w]], [[4w9x|4w9x]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BMP2K, BIKE, HRIHFB2017 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3r OCA], [http://pdbe.org/5i3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3r RCSB], [http://www.ebi.ac.uk/pdbsum/5i3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i3r OCA], [http://pdbe.org/5i3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i3r RCSB], [http://www.ebi.ac.uk/pdbsum/5i3r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i3r ProSAT]</span></td></tr>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith, C H]]

Revision as of 06:22, 17 April 2019

Crystal Structure of BMP-2-inducible kinase in complex with an Indazole inhibitor

PDB ID 5i3r

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