6i28
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i28 OCA], [http://pdbe.org/6i28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i28 RCSB], [http://www.ebi.ac.uk/pdbsum/6i28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i28 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i28 OCA], [http://pdbe.org/6i28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i28 RCSB], [http://www.ebi.ac.uk/pdbsum/6i28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i28 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Many viral genomes encode kinase and phosphatase enzymes to manipulate pathways that are controlled by phosphorylation events. The majority of viral phosphatase genes occur in the Baculoviridae and Poxviridae families of large DNA viruses. The corresponding protein sequences belong to four major homology groups, and structures are currently available for only two of these. Here, the first structure from the third group, the protein tyrosine phosphatase-2 (PTP-2) class of viral phosphatases, is described. It is shown that Cydia pomonella granulovirus PTP-2 has the same general fold and active-site architecture as described previously for other phosphatases, in the absence of significant sequence homology. Additionally, it has a novel C-terminal extension in an area corresponding to the interface of dimeric poxvirus phosphatases belonging to the Tyr-Ser protein phosphatase homology group. | ||
| + | |||
| + | Crystal structure of protein tyrosine phosphatase-2 from Cydia pomonella granulovirus.,Huang G, Oliver MR, Keown JR, Goldstone DC, Metcalf P Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):233-238. doi:, 10.1107/S2053230X19002322. Epub 2019 Mar 13. PMID:30950823<ref>PMID:30950823</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6i28" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal Structure of Cydia Pomonella PTP-2 phosphatase
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