6i3g
From Proteopedia
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<StructureSection load='6i3g' size='340' side='right'caption='[[6i3g]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='6i3g' size='340' side='right'caption='[[6i3g]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6i3g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I3G FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6i3g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_difficilis"_hall_and_o'toole_1935 "bacillus difficilis" hall and o'toole 1935]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I3G FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">appA, appA_1, BGU81_05565, BN1095_250054, BN1096_520027, BN1097_680156, SAMEA3374989_00890 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 "Bacillus difficilis" Hall and O'Toole 1935])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i3g OCA], [http://pdbe.org/6i3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i3g RCSB], [http://www.ebi.ac.uk/pdbsum/6i3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i3g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i3g OCA], [http://pdbe.org/6i3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i3g RCSB], [http://www.ebi.ac.uk/pdbsum/6i3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i3g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Peptides play an important signalling role in Bacillus subtilis, where their uptake by one of two ABC-type oligopeptide transporters, Opp and App, is required for efficient sporulation. Homologues of these transporters in Clostridium difficile have been characterized, but their role, and hence that of peptides, in regulating sporulation in this organism is less clear. Here, the oligopeptide-binding receptor proteins for these transporters, CdAppA and CdOppA, have been purified and partially characterized, and the crystal structure of CdAppA has been determined in an open unliganded form. Peptide binding to either protein could not be observed in Thermofluor assays with a set of ten peptides of varying lengths and compositions. Re-examination of the protein sequences together with structure comparisons prompts the proposal that CdAppA is not a versatile peptide-binding protein but instead may bind a restricted set of peptides. Meanwhile, CdOppA is likely to be the receptor protein for a nickel-uptake system. | ||
| + | |||
| + | Crystal structure of the putative peptide-binding protein AppA from Clostridium difficile.,Hughes A, Wilson S, Dodson EJ, Turkenburg JP, Wilkinson AJ Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):246-253. doi:, 10.1107/S2053230X1900178X. Epub 2019 Mar 13. PMID:30950825<ref>PMID:30950825</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6i3g" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Bacillus difficilis hall and o'toole 1935]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Dodson, E]] | [[Category: Dodson, E]] | ||
Current revision
Crystal structure of a putative peptide binding protein AppA from Clostridium difficile
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