Journal:Acta Cryst D:S2059798319002304
From Proteopedia
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*a) <scene name='81/813414/Cv/3'>Two-fold non-crystallographic symmetry axis, pairwise connecting molecules A-B and C-D, is parallel to the plane of the figure</scene>. | *a) <scene name='81/813414/Cv/3'>Two-fold non-crystallographic symmetry axis, pairwise connecting molecules A-B and C-D, is parallel to the plane of the figure</scene>. | ||
*b) <scene name='81/813414/Cv/4'>Molecules form a structure resembling an armchair</scene>. | *b) <scene name='81/813414/Cv/4'>Molecules form a structure resembling an armchair</scene>. | ||
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| + | <scene name='81/813414/Cv/7'>TextToBeDisplayed</scene> | ||
| + | It was noted above that in molecule E the conformation of the contact region of the γ-subunit with the � subunit (switch 3) is fundamentally different from the conformation of this region in the molecules in pairs A–B and C–D. In molecule E (Fig. 3a) the conformation of switch 3 is as previously found in free SsoIF2� (Yatime et al., 2007; Nikonov et al., 2007, 2016; Dubiez et al., 2015), the �/� heterodimer (Yatime et al., 2006) and the full SsoIF2 factor (Stolboushkina et al., 2008). In all of these structures the �-hairpin corresponding to loop �L1 protrudes outwards from the body of the molecule and the conformation of switch 3 is therefore called ‘open’. Switch 3 of molecule E can be superimposed on the corresponding region of the SsoIF2�– GDPCP structure containing Mg2+ (Nikonov et al., 2016) with an r.m.s.d. of 1.45 Å. | ||
<b>References</b><br> | <b>References</b><br> | ||
Revision as of 12:57, 22 April 2019
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