2uu9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2uu9.gif|left|200px]]
[[Image:2uu9.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2uu9 |SIZE=350|CAPTION= <scene name='initialview01'>2uu9</scene>, resolution 3.10&Aring;
+
The line below this paragraph, containing "STRUCTURE_2uu9", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5&#39;-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CM0:5-(CARBOXYMETHOXY)+URIDINE-5&#39;-MONOPHOSPHATE'>CM0</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PAR:PAROMOMYCIN'>PAR</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2uu9| PDB=2uu9 | SCENE= }}
-
|RELATEDENTRY=[[1fjg|1FJG]], [[1gix|1GIX]], [[1i94|1I94]], [[1i95|1I95]], [[1i96|1I96]], [[1i97|1I97]], [[1ibk|1IBK]], [[1ibl|1IBL]], [[1ibm|1IBM]], [[1j5e|1J5E]], [[1jgo|1JGO]], [[1jgp|1JGP]], [[1jgq|1JGQ]], [[1l1u|1L1U]], [[1n32|1N32]], [[1n33|1N33]], [[1n34|1N34]], [[1n36|1N36]], [[1pns|1PNS]], [[1pnx|1PNX]], [[1xmo|1XMO]], [[1xmq|1XMQ]], [[1xnq|1XNQ]], [[1xnr|1XNR]], [[1yl4|1YL4]], [[2b64|2B64]], [[2b9m|2B9M]], [[2b9o|2B9O]], [[2f4v|2F4V]], [[2j00|2J00]], [[2j02|2J02]], [[2uua|2UUA]], [[2uub|2UUB]], [[2uuc|2UUC]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uu9 OCA], [http://www.ebi.ac.uk/pdbsum/2uu9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uu9 RCSB]</span>
+
-
}}
+
'''STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT COMPLEXED WITH A VALINE-ASL WITH CMO5U IN POSITION 34 BOUND TO AN MRNA WITH A GUG-CODON IN THE A-SITE AND PAROMOMYCIN.'''
'''STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT COMPLEXED WITH A VALINE-ASL WITH CMO5U IN POSITION 34 BOUND TO AN MRNA WITH A GUG-CODON IN THE A-SITE AND PAROMOMYCIN.'''
Line 32: Line 29:
[[Category: Vendeix, F A.P.]]
[[Category: Vendeix, F A.P.]]
[[Category: Weixlbaumer, A.]]
[[Category: Weixlbaumer, A.]]
-
[[Category: cmo5u]]
+
[[Category: Cmo5u]]
-
[[Category: coiled coil]]
+
[[Category: Coiled coil]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: modifiaction]]
+
[[Category: Modifiaction]]
-
[[Category: mrna]]
+
[[Category: Mrna]]
-
[[Category: paromomycin]]
+
[[Category: Paromomycin]]
-
[[Category: ribonucleoprotein]]
+
[[Category: Ribonucleoprotein]]
-
[[Category: ribosomal protein]]
+
[[Category: Ribosomal protein]]
-
[[Category: ribosome]]
+
[[Category: Ribosome]]
-
[[Category: rna-binding]]
+
[[Category: Rna-binding]]
-
[[Category: rrna-binding]]
+
[[Category: Rrna-binding]]
-
[[Category: translation]]
+
[[Category: Translation]]
-
[[Category: trna]]
+
[[Category: Trna]]
-
[[Category: trna-binding]]
+
[[Category: Trna-binding]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
[[Category: zinc-finger]]
+
[[Category: Zinc-finger]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 9 14:41:57 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:04:31 2008''
+

Revision as of 11:41, 9 April 2008

Image:2uu9.gif

Template:STRUCTURE 2uu9

STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT COMPLEXED WITH A VALINE-ASL WITH CMO5U IN POSITION 34 BOUND TO AN MRNA WITH A GUG-CODON IN THE A-SITE AND PAROMOMYCIN.


Overview

One of the most prevalent base modifications involved in decoding is uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known for several decades that this modification enables a single tRNA to decode all four codons in a degenerate codon box. We have determined structures of an anticodon stem-loop of tRNA(Val) containing the modified uridine with all four valine codons in the decoding site of the 30S ribosomal subunit. An intramolecular hydrogen bond involving the modification helps to prestructure the anticodon loop. We found unusual base pairs with the three noncomplementary codon bases, including a G.U base pair in standard Watson-Crick geometry, which presumably involves an enol form for the uridine. These structures suggest how a modification in the uridine at the wobble position can expand the decoding capability of a tRNA.

About this Structure

2UU9 is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines., Weixlbaumer A, Murphy FV 4th, Dziergowska A, Malkiewicz A, Vendeix FA, Agris PF, Ramakrishnan V, Nat Struct Mol Biol. 2007 Jun;14(6):498-502. Epub 2007 May 13. PMID:17496902 Page seeded by OCA on Wed Apr 9 14:41:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2uu9"
Personal tools