2zbk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2zbk.jpg|left|200px]]
[[Image:2zbk.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2zbk |SIZE=350|CAPTION= <scene name='initialview01'>2zbk</scene>, resolution 3.560&Aring;
+
The line below this paragraph, containing "STRUCTURE_2zbk", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Rdc+Binding+Site+For+Residue+B+531'>AC1</scene>, <scene name='pdbsite=AC2:Rdc+Binding+Site+For+Residue+D+531'>AC2</scene>, <scene name='pdbsite=AC3:Rdc+Binding+Site+For+Residue+F+531'>AC3</scene> and <scene name='pdbsite=AC4:Rdc+Binding+Site+For+Residue+H+531'>AC4</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=RDC:RADICICOL'>RDC</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= top6A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2286 Sulfolobus shibatae]), top6B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2286 Sulfolobus shibatae])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00223 TOPRIM_TopoIIB_SPO], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam04406 TP6A_N], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04342 PRK04342], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK05179 rpsM], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1389 COG1389], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00823 TopoIIB_Trans], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00075 HATPase_c]</span>
+
{{STRUCTURE_2zbk| PDB=2zbk | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zbk OCA], [http://www.ebi.ac.uk/pdbsum/2zbk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2zbk RCSB]</span>
+
-
}}
+
'''Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms'''
'''Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms'''
Line 23: Line 20:
==Reference==
==Reference==
Crystal Structure of an Intact Type II DNA Topoisomerase: Insights into DNA Transfer Mechanisms., Graille M, Cladiere L, Durand D, Lecointe F, Gadelle D, Quevillon-Cheruel S, Vachette P, Forterre P, van Tilbeurgh H, Structure. 2008 Mar;16(3):360-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18334211 18334211]
Crystal Structure of an Intact Type II DNA Topoisomerase: Insights into DNA Transfer Mechanisms., Graille M, Cladiere L, Durand D, Lecointe F, Gadelle D, Quevillon-Cheruel S, Vachette P, Forterre P, van Tilbeurgh H, Structure. 2008 Mar;16(3):360-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18334211 18334211]
-
[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
 
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Sulfolobus shibatae]]
[[Category: Sulfolobus shibatae]]
Line 32: Line 28:
[[Category: Lecointe, F.]]
[[Category: Lecointe, F.]]
[[Category: Tilbeurgh, H van.]]
[[Category: Tilbeurgh, H van.]]
-
[[Category: atp-binding]]
+
[[Category: YSG, Paris-Sud Yeast Structural Genomics.]]
-
[[Category: atpase]]
+
[[Category: Atp-binding]]
-
[[Category: decatenation]]
+
[[Category: Atpase]]
-
[[Category: dna binding protein]]
+
[[Category: Decatenation]]
-
[[Category: dna topoisomerase]]
+
[[Category: Dna binding protein]]
-
[[Category: dna-binding]]
+
[[Category: Dna topoisomerase]]
-
[[Category: drug design]]
+
[[Category: Dna-binding]]
-
[[Category: magnesium]]
+
[[Category: Drug design]]
-
[[Category: metal-binding]]
+
[[Category: Magnesium]]
-
[[Category: nucleotide-binding]]
+
[[Category: Metal-binding]]
-
 
+
[[Category: Nucleotide-binding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:32:34 2008''
+
[[Category: Paris-sud yeast structural genomic]]
 +
[[Category: Structural genomic]]
 +
[[Category: Ysg]]
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 9 14:43:57 2008''

Revision as of 11:43, 9 April 2008

Image:2zbk.jpg

Template:STRUCTURE 2zbk

Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms


Overview

DNA topoisomerases resolve DNA topological problems created during transcription, replication, and recombination. These ubiquitous enzymes are essential for cell viability and are highly potent targets for the development of antibacterial and antitumoral drugs. Type II enzymes catalyze the transfer of a DNA duplex through another one in an ATP-dependent mechanism. Because of its small size and sensitivity to antitumoral drugs, the archaeal DNA topoisomerase VI, a type II enzyme, is an excellent model for gaining further understanding of the organization and mechanism of these enzymes. We present the crystal structure of intact DNA topoisomerase VI bound to radicicol, an inhibitor of human topo II, and compare it to the conformation of the apo-protein as determined by small-angle X-ray scattering in solution. This structure, combined with a wealth of experimental data gathered on these enzymes, allows us to propose a structural model for the two-gate DNA transfer mechanism.

About this Structure

2ZBK is a Protein complex structure of sequences from Sulfolobus shibatae. Full crystallographic information is available from OCA.

Reference

Crystal Structure of an Intact Type II DNA Topoisomerase: Insights into DNA Transfer Mechanisms., Graille M, Cladiere L, Durand D, Lecointe F, Gadelle D, Quevillon-Cheruel S, Vachette P, Forterre P, van Tilbeurgh H, Structure. 2008 Mar;16(3):360-70. PMID:18334211 Page seeded by OCA on Wed Apr 9 14:43:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zbk"
Personal tools