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6gfl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Escherichia coli nucleosidase PpnN (apo form)== | |
| - | + | <StructureSection load='6gfl' size='340' side='right'caption='[[6gfl]], [[Resolution|resolution]] 2.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gfl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GFL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6gfm|6gfm]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gfl OCA], [http://pdbe.org/6gfl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gfl RCSB], [http://www.ebi.ac.uk/pdbsum/6gfl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gfl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PPNN_ECOLI PPNN_ECOLI]] Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base. Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. Cannot catalyze the reverse reactions. Is required for optimal growth in glucose minimal medium, possibly because it contributes to nucleoside pool homeostasis by degrading excess nucleotides and feeding back the ribose moiety to catabolism.<ref>PMID:27941785</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baerentsen, R L]] | ||
| + | [[Category: Brodersen, D E]] | ||
| + | [[Category: Gerdes, K]] | ||
| + | [[Category: Zhang, Y]] | ||
| + | [[Category: Allosteric enzyme]] | ||
| + | [[Category: Antibiotic tolerance]] | ||
| + | [[Category: Fluoroquinolone]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Nucleotide metabolism]] | ||
| + | [[Category: Persistence]] | ||
| + | [[Category: Ppnn]] | ||
| + | [[Category: Stringent response]] | ||
| + | [[Category: Ygdh]] | ||
Revision as of 06:46, 24 April 2019
Crystal structure of the Escherichia coli nucleosidase PpnN (apo form)
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