6q30
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of NDM-1 beta-lactamase in complex with boronic inhibitor cpd 5== | |
| - | + | <StructureSection load='6q30' size='340' side='right'caption='[[6q30]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6q30]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q30 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HCH:(7-carboxy-1-benzothiophen-2-yl)-tris(oxidanyl)boranuide'>HCH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q30 OCA], [http://pdbe.org/6q30 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q30 RCSB], [http://www.ebi.ac.uk/pdbsum/6q30 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q30 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Beta-lactamase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bellio, P]] | ||
[[Category: Celenza, G]] | [[Category: Celenza, G]] | ||
| - | [[Category: Quotadamo, A]] | ||
[[Category: Cendron, L]] | [[Category: Cendron, L]] | ||
| - | [[Category: | + | [[Category: Costi, M P]] |
| - | [[Category: | + | [[Category: Maso, L]] |
[[Category: Montanari, M]] | [[Category: Montanari, M]] | ||
| + | [[Category: Quotadamo, A]] | ||
[[Category: Tondi, D]] | [[Category: Tondi, D]] | ||
| - | [[Category: | + | [[Category: Venturelli, A]] |
| - | [[Category: | + | [[Category: Acyclic boronic inhibitor]] |
| + | [[Category: Bacterial resistance]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 07:08, 24 April 2019
Crystal structure of NDM-1 beta-lactamase in complex with boronic inhibitor cpd 5
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