5is5
From Proteopedia
(Difference between revisions)
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==Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors== | ==Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors== | ||
| - | <StructureSection load='5is5' size='340' side='right' caption='[[5is5]], [[Resolution|resolution]] 2.85Å' scene=''> | + | <StructureSection load='5is5' size='340' side='right'caption='[[5is5]], [[Resolution|resolution]] 2.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5is5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IS5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5is5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IS5 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6CY:5-{4-[3-(4-ACETYLPIPERAZINE-1-CARBONYL)PHENYL]QUINAZOLIN-6-YL}-2-METHOXYPYRIDINE-3-CARBONITRILE'>6CY</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6CY:5-{4-[3-(4-ACETYLPIPERAZINE-1-CARBONYL)PHENYL]QUINAZOLIN-6-YL}-2-METHOXYPYRIDINE-3-CARBONITRILE'>6CY</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pik3cd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5is5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5is5 OCA], [http://pdbe.org/5is5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5is5 RCSB], [http://www.ebi.ac.uk/pdbsum/5is5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5is5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5is5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5is5 OCA], [http://pdbe.org/5is5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5is5 RCSB], [http://www.ebi.ac.uk/pdbsum/5is5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5is5 ProSAT]</span></td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | [[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]] | ||
[[Category: Gutmann, S]] | [[Category: Gutmann, S]] | ||
Revision as of 07:36, 24 April 2019
Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors
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