6i5m

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==Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus in complex with GDP and formate ion==
==Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus in complex with GDP and formate ion==
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<StructureSection load='6i5m' size='340' side='right' caption='[[6i5m]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='6i5m' size='340' side='right'caption='[[6i5m]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6i5m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I5M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6i5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I5M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">eif2g, SSO0412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5m OCA], [http://pdbe.org/6i5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i5m RCSB], [http://www.ebi.ac.uk/pdbsum/6i5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5m OCA], [http://pdbe.org/6i5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i5m RCSB], [http://www.ebi.ac.uk/pdbsum/6i5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
[[http://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the gamma subunit of archaeal translation initiation factor 2 (aIF2) from Sulfolobus solfataricus (SsoIF2gamma) was determined in complex with GDPCP (a GTP analog). Crystals were obtained in the absence of magnesium ions in the crystallization solution. They belonged to space group P1, with five molecules in the unit cell. Four of these molecules are related in pairs by a common noncrystallographic twofold symmetry axis, while the fifth has no symmetry equivalent. Analysis of the structure and its comparison with other known aIF2 gamma-subunit structures in the GTP-bound state show that (i) the magnesium ion is necessary for the formation and the maintenance of the active form of SsoIF2gamma and (ii) in addition to the two previously known structural switches 1 and 2, eukaryotic translation initiation factor 2 (eIF2) and aIF2 molecules have another flexible region (switch 3), the function of which may consist of initiation of the hydrolysis of GTP and the removal of e/aIF2 from the ribosome after codon-anticodon recognition.
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The third structural switch in the archaeal translation initiation factor 2 (aIF2) molecule and its possible role in the initiation of GTP hydrolysis and the removal of aIF2 from the ribosome.,Nikonov O, Kravchenko O, Nevskaya N, Stolboushkina E, Garber M, Nikonov S Acta Crystallogr D Struct Biol. 2019 Apr 1;75(Pt 4):392-399. doi:, 10.1107/S2059798319002304. Epub 2019 Mar 28. PMID:30988256<ref>PMID:30988256</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6i5m" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 35091]]
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[[Category: Large Structures]]
[[Category: Arkhipova, V]]
[[Category: Arkhipova, V]]
[[Category: Gabdulkhakov, A]]
[[Category: Gabdulkhakov, A]]

Revision as of 08:13, 24 April 2019

Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus in complex with GDP and formate ion

PDB ID 6i5m

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