4qsx
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 3'-deoxy thymidine== | ==Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 3'-deoxy thymidine== | ||
| - | <StructureSection load='4qsx' size='340' side='right' caption='[[4qsx]], [[Resolution|resolution]] 1.93Å' scene=''> | + | <StructureSection load='4qsx' size='340' side='right'caption='[[4qsx]], [[Resolution|resolution]] 1.93Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4qsx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QSX FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4qsx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QSX FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38S:1-[(2R,5S)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>38S</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38S:1-[(2R,5S)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>38S</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qsp|4qsp]], [[4qsq|4qsq]], [[4qsr|4qsr]], [[4qss|4qss]], [[4qst|4qst]], [[4qsu|4qsu]], [[4qsv|4qsv]], [[4qsw|4qsw]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qsp|4qsp]], [[4qsq|4qsq]], [[4qsr|4qsr]], [[4qss|4qss]], [[4qst|4qst]], [[4qsu|4qsu]], [[4qsv|4qsv]], [[4qsw|4qsw]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsx OCA], [http://pdbe.org/4qsx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qsx RCSB], [http://www.ebi.ac.uk/pdbsum/4qsx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qsx OCA], [http://pdbe.org/4qsx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qsx RCSB], [http://www.ebi.ac.uk/pdbsum/4qsx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qsx ProSAT]</span></td></tr> | ||
| Line 11: | Line 12: | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | [[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 16: | Line 20: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Adenosinetriphosphatase]] | [[Category: Adenosinetriphosphatase]] | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 08:41, 24 April 2019
Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 3'-deoxy thymidine
| |||||||||||
Categories: Adenosinetriphosphatase | Human | Large Structures | Arrowsmith, C H | Bountra, C | Chaikuad, A | Delft, F von | Edwards, A M | Felletar, I | Knapp, S | Structural genomic | Actyl-lysine binding | Atpase family aaa domain-containing protein 2 | Bromodomain | Epigenetic | Signaling protein
