4qh4
From Proteopedia
(Difference between revisions)
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==The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in acetate buffer at pH3== | ==The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in acetate buffer at pH3== | ||
| - | <StructureSection load='4qh4' size='340' side='right' caption='[[4qh4]], [[Resolution|resolution]] 3.20Å' scene=''> | + | <StructureSection load='4qh4' size='340' side='right'caption='[[4qh4]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4qh4]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4qh4]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qh5|4qh5]], [[4qh1|4qh1]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qh5|4qh5]], [[4qh1|4qh1]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glvI, glr4197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=251221 GLOVI])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh4 OCA], [http://pdbe.org/4qh4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qh4 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh4 OCA], [http://pdbe.org/4qh4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qh4 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | [[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
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| + | ==See Also== | ||
| + | *[[Ion channels|Ion channels]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Glovi]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Delarue, M]] | [[Category: Delarue, M]] | ||
[[Category: Fourati, Z]] | [[Category: Fourati, Z]] | ||
Revision as of 08:42, 24 April 2019
The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in acetate buffer at pH3
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