4qob
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of cPOP1== | |
| - | + | <StructureSection load='4qob' size='340' side='right'caption='[[4qob]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4qob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QOB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYDC1, ASC2, ASCI, POP1, PYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qob OCA], [http://pdbe.org/4qob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qob RCSB], [http://www.ebi.ac.uk/pdbsum/4qob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qob ProSAT]</span></td></tr> |
| - | [[Category: Park, H | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PYDC1_HUMAN PYDC1_HUMAN]] Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.<ref>PMID:12656673</ref> <ref>PMID:24871464</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Park, H H]] | ||
| + | [[Category: Death domain superfamily]] | ||
| + | [[Category: Protein binding]] | ||
Revision as of 09:13, 24 April 2019
Crystal structure of cPOP1
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