Casein kinase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
| - | CK2 is a tetramer | + | CK2 is a tetramer which contains α and α' subunits (CK2A1 and CK2A2) which are the catalytic ones and two β subunits which are the regulatory ones. <scene name='46/468136/Cv/4'>CK1 inhibitors bind in the ATP binding pocket</scene>. <ref>PMID:22877629</ref> Water molecules are shown as red spheres. |
</StructureSection> | </StructureSection> | ||
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**[[2csn]], [[1eh4]] – yCK1 catalytic domain + inhibitor | **[[2csn]], [[1eh4]] – yCK1 catalytic domain + inhibitor | ||
| - | * | + | *CK2A1 catalytic subunit |
**[[1pjk]], [[3at2]], [[3q04]], [[3qa0]], [[3war]], [[3ofm]], [[5t1h]] - hCK2 <br /> | **[[1pjk]], [[3at2]], [[3q04]], [[3qa0]], [[3war]], [[3ofm]], [[5t1h]] - hCK2 <br /> | ||
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**[[1lpu]], [[1lr4]], [[1jam]] - mCK2 <br /> | **[[1lpu]], [[1lr4]], [[1jam]] - mCK2 <br /> | ||
| - | * | + | *CK2A1 catalytic subunit binary complex |
**[[3u87]] – hCK2 + ATP analog<br /> | **[[3u87]] – hCK2 + ATP analog<br /> | ||
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**[[4jr7]], [[4lfi]] - yCK2 + GMPPNP<br /> | **[[4jr7]], [[4lfi]] - yCK2 + GMPPNP<br /> | ||
**[[5xvu]] - CK2 + ATP – ''Plasmodium falciparum''<br /> | **[[5xvu]] - CK2 + ATP – ''Plasmodium falciparum''<br /> | ||
| + | |||
| + | *CK2A2 catalytic subunit | ||
*CK2 regulatory subunit | *CK2 regulatory subunit | ||
Revision as of 09:09, 25 April 2019
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3D Structures of casein kinase
Updated on 25-April-2019
References
- ↑ Eide EJ, Virshup DM. Casein kinase I: another cog in the circadian clockworks. Chronobiol Int. 2001 May;18(3):389-98. PMID:11475410
- ↑ Pinna LA, Meggio F. Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation. Prog Cell Cycle Res. 1997;3:77-97. PMID:9552408
- ↑ Hua Z, Huang X, Bregman H, Chakka N, DiMauro EF, Doherty EM, Goldstein J, Gunaydin H, Huang H, Mercede S, Newcomb J, Patel VF, Turci SM, Yan J, Wilson C, Martin MW. 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1gamma) inhibitors. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5392-5. doi: 10.1016/j.bmcl.2012.07.046. , Epub 2012 Jul 20. PMID:22877629 doi:10.1016/j.bmcl.2012.07.046
