2bze

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[[Image:2bze.gif|left|200px]]
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{{Structure
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{{STRUCTURE_2bze| PDB=2bze | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bze OCA], [http://www.ebi.ac.uk/pdbsum/2bze PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bze RCSB]</span>
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'''NMR STRUCTURE OF HUMAN RTF1 PLUS3 DOMAIN.'''
'''NMR STRUCTURE OF HUMAN RTF1 PLUS3 DOMAIN.'''
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[[Category: Spine, Structural Proteomics in Europe.]]
[[Category: Spine, Structural Proteomics in Europe.]]
[[Category: Truffault, V.]]
[[Category: Truffault, V.]]
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[[Category: cdc73]]
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[[Category: Cdc73]]
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[[Category: ctr9]]
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[[Category: Ctr9]]
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[[Category: elongation]]
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[[Category: Elongation]]
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[[Category: h2b ubiquitination]]
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[[Category: H2b ubiquitination]]
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[[Category: histone h3 methylation]]
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[[Category: Histone h3 methylation]]
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[[Category: human rtf1 plus3 domain]]
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[[Category: Human rtf1 plus3 domain]]
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[[Category: leo1]]
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[[Category: Leo1]]
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[[Category: paf1 complex]]
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[[Category: Paf1 complex]]
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[[Category: plus3 domain]]
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[[Category: Plus3 domain]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:03:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:03 2008''
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Revision as of 05:03, 13 April 2008

Image:2bze.gif

Template:STRUCTURE 2bze

NMR STRUCTURE OF HUMAN RTF1 PLUS3 DOMAIN.


Overview

The yeast Paf1 complex consists of Paf1, Rtf1, Cdc73, Ctr9, and Leo1 and regulates histone H2B ubiquitination, histone H3 methylation, RNA polymerase II carboxy-terminal domain (CTD) Ser2 phosphorylation, and RNA 3' end processing. We provide structural insight into the Paf1 complex with the NMR structure of the conserved and functionally important Plus3 domain of human Rtf1. A predominantly beta-stranded subdomain displays structural similarity to Dicer/Argonaute PAZ domains and to Tudor domains. We further demonstrate that the highly basic Rtf1 Plus3 domain can interact in vitro with single-stranded DNA via residues on the rim of the beta sheet, reminiscent of siRNA binding by PAZ domains, but did not detect binding to double-stranded DNA or RNA. We discuss the potential role of Rtf1 Plus3 ssDNA binding during transcription elongation.

About this Structure

2BZE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and DNA binding of the human Rtf1 Plus3 domain., de Jong RN, Truffault V, Diercks T, Ab E, Daniels MA, Kaptein R, Folkers GE, Structure. 2008 Jan;16(1):149-59. PMID:18184592 Page seeded by OCA on Sun Apr 13 08:03:26 2008

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