Caspase
From Proteopedia
(Difference between revisions)
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of caspase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *CASP-1 | ||
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| - | **[[3e4c]] – hpro-CASP (mutant) - human<br /> | ||
| - | **[[2nn3]] – pro-SfCASP (mutant) – ''Spodoptera frugiperda''<br /> | ||
| - | **[[5fna]] – hCASP CARD domain – Cryo-EM<br /> | ||
| - | **[[1sc1]], [[1sc4]] - hCASP (mutant) <br /> | ||
| - | **[[1sc3]] - hCASP (mutant) + malonate<br /> | ||
| - | **[[6bz9]] - hCASP + polypeptide inhibitor<br /> | ||
| - | **[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]], [[5mtk]], [[5mmv]], [[6f6r]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
| - | **[[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br /> | ||
| - | **[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br /> | ||
| - | **[[1ice]] – hCASP + tetrapeptide aldehyde<br /> | ||
| - | **[[1m72]] – SfCASP + polypeptide inhibitor<br /> | ||
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| - | *CASP-2 | ||
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| - | **[[2p2c]] – hCASP<br /> | ||
| - | **[[3r7s]] - hCASP subunits P12, P18<br /> | ||
| - | **[[1pyo]], [[3r5j]], [[3r6g]], [[3r6l]], [[3r7b]], [[3r7n]], [[3rjm]] - hCASP + polypeptide inhibitor<br /> | ||
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| - | *CASP-3 | ||
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| - | **[[1qx3]] - hCASP<br /> | ||
| - | **[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br /> | ||
| - | **[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br /> | ||
| - | **[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]], [[4pry]] – hCASP + polypeptide inhibitor<br /> | ||
| - | **[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]], [[4ps0]], [[4ps1]] – hCASP subunits P12, P17 + polypeptide inhibitor<br /> | ||
| - | **[[2dko]], [[2cjx]], [[2cjy]], [[4qtx]], [[4qty]], [[4qu0]], [[4qu5]], [[4qu8]], [[4qu9]], [[4qua]], [[4qub]] [[4qud]], [[4que]], [[4qug]], [[4quh]], [[4qui]], [[4quj]], [[4qul]], [[5i9b]], [[5i9t]], [[5iab]], [[5iae]], [[5iag]], [[5iaj]], [[5iak]], [[5ian]], [[5iar]], [[5ias]], [[5ibc]], [[5ibp]], [[5ibr]], [[4qud]], [[6bfj]], [[6bfk]], [[6bfl]], [[6bfo]], [[6bg0]], [[6bg1]], [[6bg4]], [[6bgk]], [[6bgq]], [[6bgr]], [[6bgs]], [[6bh9]], [[6bha]], [[6bdv]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
| - | **[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br /> | ||
| - | **[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br /> | ||
| - | [[4jqy]], [[4jqz]] - hpro-CASP (mutant)<br /> | ||
| - | **[[1i3o]] - hCASP (mutant) + XIAP-BIR2 | ||
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| - | *CASP-6 | ||
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| - | **[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br /> | ||
| - | **[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]], [[6dev]], [[6deu]] – hCASP (mutant) <br /> | ||
| - | **[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br /> | ||
| - | **[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br /> | ||
| - | **[[4fxo]] - hCASP subunit P11 + P18 + Zn<br /> | ||
| - | **[[4hva]] - hCASP subunit P11 + P18 + VEID inhibitor<br /> | ||
| - | **[[4n5d]] - hCASP subunit P11 + P18 + inhibitor<br /> | ||
| - | **[[4n6g]], [[4n7j]], [[4n7m]], [[4nbk]], [[4nbl]], [[4nbn]] - hCASP subunit P11 + P18 (mutant) + inhibitor<br /> | ||
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| - | *CASP-7 | ||
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| - | **[[3rk5]], [[4fdl]] - hCASP<br /> | ||
| - | **[[5k20]] – hCASP large + small (mutant) subunits<br /> | ||
| - | **[[3ibf]] – hCASP large subunit<br /> | ||
| - | **[[3r5k]], [[4hq0]] - hCASP (mutant) <br /> | ||
| - | **[[1k86]], [[1gqf]] – hCASP catalytic domain<br /> | ||
| - | **[[1k88]] – hpro-CASP (mutant) <br /> | ||
| - | **[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP large subunit + polypeptide inhibitor<br /> | ||
| - | **[[1f1j]], [[4hqr]] - hCASP + polypeptide inhibitor<br /> | ||
| - | **[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br /> | ||
| - | **[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br /> | ||
| - | **[[4fea]], [[5v6z]], [[5v6u]] - hCASP catalytic domain + inhibitor<br /> | ||
| - | **[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br /> | ||
| - | **[[1i4o]] - hCASP P20 subunit + XIAP<br /> | ||
| - | **[[4jb8]], [[4lsz]] - hCASP large+small subunits + DARPIN<br /> | ||
| - | **[[5ic6]], [[5ic4]], [[4zvo]], [[4zvp]], [[4zvq]], [[4zvr]], [[4zvs]], [[4zvt]], [[4zvu]], [[6cl2]], [[6cl1]], [[6cl0]], [[6ckz]] - hCASP large+small subunits + peptide inhibitor<br /> | ||
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| - | *CASP-8 | ||
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| - | **[[5l08]] – hCASP – Cryo-EM<br /> | ||
| - | **[[4zbw]] - hCASP death effector domain<br /> | ||
| - | **[[5h33]], [[5h31]] - hCASP death effector domain (mutant)<br /> | ||
| - | **[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br /> | ||
| - | **[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br /> | ||
| - | **[[1qtn]], [[4jj7]], [[4jj8]], [[4prz]] - hCASP P18, P11 + polypeptide inhibitor<br /> | ||
| - | **[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br /> | ||
| - | **[[2y1l]] - hCASP subunits P18 P10<br /> | ||
| - | **[[2k7z]] – hpro-CASP (mutant) – NMR<br /> | ||
| - | **[[2fun]], [[1i4e]] – CASP + P35 – ''Autographa californica'' | ||
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| - | *CASP-9 | ||
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| - | **[[2ar9]] – hCASP (mutant) <br /> | ||
| - | **[[1jxq]] - hCASP + polypeptide inhibitor<br /> | ||
| - | **[[3v3k]] – hCASP + effector protein<br /> | ||
| - | **[[5wve]], [[5juy]], [[5wvc]] – hCASP CARD domain + APAF-1<br /> | ||
| - | **[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br /> | ||
| - | **[[3ygs]], [[4rhw]] – hpro-CASP + APAF-1 CARD | ||
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| - | *''Drosophila melanogaster'' CASP | ||
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| - | **[[2fp3]] – DmCASP Dronc residues 136-450 – ''Drosophila melanogaster''<br /> | ||
| - | **[[3sir]] - DmCASP drICE residues 78-332<br /> | ||
| - | **[[3sip]] – DmCASP drICE residues 78-230 + apoptosis inhibitor<br /> | ||
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| - | *Metacaspase | ||
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| - | **[[4afp]], [[4afr]], [[4afv]], [[4af8]] – MCASP (mutant) – ''Trypanosom brucei''<br /> | ||
| - | **[[4f6o]] – yMCASP 1 – yeast<br /> | ||
| - | **[[4f6p]] – yMCASP 1 (mutant)<br /> | ||
| - | }} | ||
== References == | == References == | ||
Revision as of 09:59, 28 April 2019
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References
- ↑ Schweizer A, Briand C, Grutter MG. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J Biol Chem. 2003 Oct 24;278(43):42441-7. Epub 2003 Aug 14. PMID:12920126 doi:http://dx.doi.org/10.1074/jbc.M304895200
- ↑ Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al.. Structure and mechanism of interleukin-1 beta converting enzyme. Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875 doi:http://dx.doi.org/10.1038/370270a0
