1dkf

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[[Image:1dkf.gif|left|200px]]
[[Image:1dkf.gif|left|200px]]
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{{Structure
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|PDB= 1dkf |SIZE=350|CAPTION= <scene name='initialview01'>1dkf</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1dkf", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BMS:4-[(4,4-DIMETHYL-1,2,3,4-TETRAHYDRO-[1,2&#39;]BINAPTHALENYL-7-CARBONYL)-AMINO]-BENZOIC+ACID'>BMS</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>
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{{STRUCTURE_1dkf| PDB=1dkf | SCENE= }}
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|RELATEDENTRY=[[1lbd|1LBD]], [[2lbd|2LBD]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dkf OCA], [http://www.ebi.ac.uk/pdbsum/1dkf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dkf RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF A HETERODIMERIC COMPLEX OF RAR AND RXR LIGAND-BINDING DOMAINS'''
'''CRYSTAL STRUCTURE OF A HETERODIMERIC COMPLEX OF RAR AND RXR LIGAND-BINDING DOMAINS'''
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[[Category: Vivat, V.]]
[[Category: Vivat, V.]]
[[Category: Wurtz, J M.]]
[[Category: Wurtz, J M.]]
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[[Category: helical sandwich]]
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[[Category: Helical sandwich]]
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[[Category: heterodimer]]
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[[Category: Heterodimer]]
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[[Category: hormone/growth factor receptor]]
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[[Category: Hormone/growth factor receptor]]
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[[Category: protein-ligand complex]]
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[[Category: Protein-ligand complex]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:05:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:43:16 2008''
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Revision as of 05:05, 13 April 2008

Image:1dkf.gif

Template:STRUCTURE 1dkf

CRYSTAL STRUCTURE OF A HETERODIMERIC COMPLEX OF RAR AND RXR LIGAND-BINDING DOMAINS


Overview

The crystal structure of a heterodimer between the ligand-binding domains (LBDs) of the human RARalpha bound to a selective antagonist and the constitutively active mouse RXRalphaF318A mutant shows that, pushed by a bulky extension of the ligand, RARalpha helix H12 adopts an antagonist position. The unexpected presence of a fatty acid in the ligand-binding pocket of RXRalpha(F318A is likely to account for its apparent "constitutivity." Specific conformational changes suggest the structural basis of pure and partial antagonism. The RAR-RXR heterodimer interface is similar to that observed in most nuclear receptor (NR) homodimers. A correlative analysis of 3D structures and sequences provides a novel view on dimerization among members of the nuclear receptor superfamily.

About this Structure

1DKF is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains., Bourguet W, Vivat V, Wurtz JM, Chambon P, Gronemeyer H, Moras D, Mol Cell. 2000 Feb;5(2):289-98. PMID:10882070 Page seeded by OCA on Sun Apr 13 08:05:56 2008

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