Cathepsin
From Proteopedia
(Difference between revisions)
| Line 46: | Line 46: | ||
* Cathepsin-B mature | * Cathepsin-B mature | ||
| - | **[[ | + | **[[2ipp]], [[1huc]] – hMCTSB<br /> |
| - | + | ||
| - | + | ||
**[[3k9m]] – hMCTSB+stefin A<br /> | **[[3k9m]] – hMCTSB+stefin A<br /> | ||
| - | **[[3ai8]] – hMCTSB + antibiotic | + | **[[3ai8]] – hMCTSB + antibiotic<br /> |
| - | + | ||
**[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin<br /> | **[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin<br /> | ||
**[[5mbl]], [[5mbm]] – hMCTSB + darpin <br /> | **[[5mbl]], [[5mbm]] – hMCTSB + darpin <br /> | ||
| Line 62: | Line 59: | ||
**[[1cpj]] - rMCTSB (mutant)<br /> | **[[1cpj]] - rMCTSB (mutant)<br /> | ||
**[[1cte]] - rMCTSB+pyrimidine inhibitor<br /> | **[[1cte]] - rMCTSB+pyrimidine inhibitor<br /> | ||
| + | **[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 <br /> | ||
| + | **[[3mor]] - TbCTSB residues 23-340<br /> | ||
| + | **[[3qsd]], [[3s3q]], [[3s3r]] - CTSB (mutant) residues 87-340+ inhibitor – ''Schistosoma mansoni''<br /> | ||
* Cathepsin-C mature or [[Dipeptidyl peptidase]]-I | * Cathepsin-C mature or [[Dipeptidyl peptidase]]-I | ||
| - | **[[2djf]], [[2djg]], [[4oel]], [[4oem]] – hMCTSC + dipeptide<br /> | ||
| - | **[[1jqp]] – rMCTSC <br /> | ||
**[[1k3b]] – hMCTSC <br /> | **[[1k3b]] – hMCTSC <br /> | ||
| + | **[[2djf]], [[2djg]], [[4oel]], [[4oem]] – hMCTSC + dipeptide<br /> | ||
**[[3pdf]], [[4cdc]], [[4cdd]], [[4cde]], [[4cdf]] – hMCTSC + inhibitor<br /> | **[[3pdf]], [[4cdc]], [[4cdd]], [[4cde]], [[4cdf]] – hMCTSC + inhibitor<br /> | ||
| + | **[[1jqp]] – rMCTSC <br /> | ||
* Cathepsin-D mature | * Cathepsin-D mature | ||
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**[[1lyb]] - hMCTSD+pepstatin<br /> | **[[1lyb]] - hMCTSD+pepstatin<br /> | ||
**[[4obz]], [[4oc6]], [[4od9]] – hMCTSD + non-peptidic inhibitor<br /> | **[[4obz]], [[4oc6]], [[4od9]] – hMCTSD + non-peptidic inhibitor<br /> | ||
| + | **[[5ux4]] – rMCTSD + inhibitor<br /> | ||
* Cathepsin-E mature | * Cathepsin-E mature | ||
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**[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br /> | **[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor<br /> | ||
**[[1t32]] - hMCTSG +piperidine inhibitor | **[[1t32]] - hMCTSG +piperidine inhibitor | ||
| + | |||
| + | *Procathepsin-H | ||
| + | |||
| + | **[[6czk]] – hPCTSH <br /> | ||
| + | **[[6czs]] – hPCTSH (mutant) <br /> | ||
* Cathepsin-H mature | * Cathepsin-H mature | ||
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**[[4n79]], [[5tun]], [[4yva]] – hMCTSK<br /> | **[[4n79]], [[5tun]], [[4yva]] – hMCTSK<br /> | ||
| - | **[[5jh3]] – hMCTSK (mutant) | + | **[[5jh3]], [[5z5o]] – hMCTSK (mutant) <br /> |
| - | + | ||
**[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br /> | **[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br /> | ||
**[[5qby]], [[5qbv]] – hMCTSK (mutant) + pyrimidine inhibitor<br /> | **[[5qby]], [[5qbv]] – hMCTSK (mutant) + pyrimidine inhibitor<br /> | ||
| Line 122: | Line 127: | ||
**[[1au2]] - hMCTSK+ propanone inhibitor<br /> | **[[1au2]] - hMCTSK+ propanone inhibitor<br /> | ||
**[[1atk]] – hMCTSK+guanidine inhibitor<br /> | **[[1atk]] – hMCTSK+guanidine inhibitor<br /> | ||
| - | **[[1vsn]], [[5j94]], [[4x6h]], [[4x6i]] - hMCTSK+ inhibitor<br /> | + | **[[1vsn]], [[5j94]], [[4x6h]], [[4x6i]], [[6qbs]] - hMCTSK+ inhibitor<br /> |
| + | **[[6ash]] – hMCTSK (mutant) + inhibitor<br /> | ||
**[[2ato]] – hMCTSK+myocrisin<br /> | **[[2ato]] – hMCTSK+myocrisin<br /> | ||
**[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br /> | **[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br /> | ||
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**[[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br /> | **[[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br /> | ||
**[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br /> | **[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br /> | ||
| + | **[[5t6u]] – mMCTSK<br /> | ||
| + | **[[6bki]] – mMCTSK (mutant) <br /> | ||
*Procathepsin-L | *Procathepsin-L | ||
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* Cathepsin-L mature | * Cathepsin-L mature | ||
| - | **[[3f75]] – MCTSL +CTSL propeptide – ''Toxoplasma gondii''<br /> | ||
| - | **[[2p86]] – TbMCTSL +K11002<br /> | ||
| - | **[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – ''Trypanosoma cruzi''<br /> | ||
**[[4axl]] – hMCTSL catalytic domain<br /> | **[[4axl]] – hMCTSL catalytic domain<br /> | ||
**[[4axm]] – hMCTSL catalytic domain + inhibitor<br /> | **[[4axm]] – hMCTSL catalytic domain + inhibitor<br /> | ||
**[[1mhw]] – hMCTSL +tripeptide<br /> | **[[1mhw]] – hMCTSL +tripeptide<br /> | ||
**[[1icf]] – hMCTSL +MHC class II fragment<br /> | **[[1icf]] – hMCTSL +MHC class II fragment<br /> | ||
| + | **[[3f75]] – MCTSL +CTSL propeptide – ''Toxoplasma gondii''<br /> | ||
| + | **[[2p86]] – TbMCTSL +K11002<br /> | ||
| + | **[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – ''Trypanosoma cruzi''<br /> | ||
* Procathepsin-L1 | * Procathepsin-L1 | ||
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**[[3kse]] – hMCTSL1 (mutant)+stefin<br /> | **[[3kse]] – hMCTSL1 (mutant)+stefin<br /> | ||
**[[4axm]], [[5mae]], [[5maj]], [[5f02]], [[3bc3]], [[3of9]] – hMCTSL1 catalytic domain + inhibitor<br /> | **[[4axm]], [[5mae]], [[5maj]], [[5f02]], [[3bc3]], [[3of9]] – hMCTSL1 catalytic domain + inhibitor<br /> | ||
| + | **[[6f06]], [[6ezx]], [[6ezp]] – hMCTSL1 catalytic domain + carboxamide inhibitor<br /> | ||
* Cathepsin-L2 mature | * Cathepsin-L2 mature | ||
Revision as of 08:50, 30 April 2019
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3D Structures of Cathepsin
Updated on 30-April-2019
References
- ↑ Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest. 2005 Feb;52(1-2):1-9. PMID:15751268
- ↑ Mirkovic B, Renko M, Turk S, Sosic I, Jevnikar Z, Obermajer N, Turk D, Gobec S, Kos J. Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds. ChemMedChem. 2011 May 20. doi: 10.1002/cmdc.201100098. PMID:21598397 doi:10.1002/cmdc.201100098
