2rli

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[[Image:2rli.jpg|left|200px]]
[[Image:2rli.jpg|left|200px]]
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{{Structure
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|PDB= 2rli |SIZE=350|CAPTION= <scene name='initialview01'>2rli</scene>
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The line below this paragraph, containing "STRUCTURE_2rli", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>
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|GENE= SCO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2rli| PDB=2rli | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rli OCA], [http://www.ebi.ac.uk/pdbsum/2rli PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rli RCSB]</span>
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'''Solution structure of Cu(I) human Sco2'''
'''Solution structure of Cu(I) human Sco2'''
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[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: Wang, S.]]
[[Category: Wang, S.]]
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[[Category: copper protein]]
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[[Category: Copper protein]]
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[[Category: metal transport]]
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[[Category: Metal transport]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: spine2-complex]]
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[[Category: Spine2-complex]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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[[Category: thioredoxin fold]]
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[[Category: Thioredoxin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:07:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:01:44 2008''
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Revision as of 05:07, 13 April 2008

Image:2rli.jpg

Template:STRUCTURE 2rli

Solution structure of Cu(I) human Sco2


Contents

Overview

Human Sco2 is a mitochondrial membrane-bound protein involved in copper supply for the assembly of cytochrome c oxidase in eukaryotes. Its precise action is not yet understood. We report here a structural and dynamic characterization by NMR of the apo and copper(I) forms of the soluble fragment. The structural and metal binding features of human Cu(I)Sco2 are similar to the more often studied Sco1 homolog, although the dynamic properties and the conformational disorder are quite different when the apo forms and the copper(I)-loaded forms of the two proteins are compared separately. Such differences are accounted for in terms of the different physicochemical properties in strategic protein locations. The misfunction of the known pathogenic mutations is discussed on the basis of the obtained structure.

Disease

Known disease associated with this structure: Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency OMIM:[604272]

About this Structure

2RLI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A structural characterization of human SCO2., Banci L, Bertini I, Ciofi-Baffoni S, Gerothanassis IP, Leontari I, Martinelli M, Wang S, Structure. 2007 Sep;15(9):1132-40. PMID:17850752 Page seeded by OCA on Sun Apr 13 08:07:07 2008

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