2jsd

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[[Image:2jsd.jpg|left|200px]]
[[Image:2jsd.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2jsd |SIZE=350|CAPTION= <scene name='initialview01'>2jsd</scene>
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The line below this paragraph, containing "STRUCTURE_2jsd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= MMP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2jsd| PDB=2jsd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [http://www.ebi.ac.uk/pdbsum/2jsd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB]</span>
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}}
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'''Solution structure of MMP20 complexed with NNGH'''
'''Solution structure of MMP20 complexed with NNGH'''
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[[Category: Gonnelli, L.]]
[[Category: Gonnelli, L.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: mmp-nngh]]
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[[Category: Mmp-nngh]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: spine-2]]
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[[Category: Spine-2]]
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[[Category: spine2-complex]]
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[[Category: Spine2-complex]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:07:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:01:19 2008''
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Revision as of 05:07, 13 April 2008

Image:2jsd.jpg

Template:STRUCTURE 2jsd

Solution structure of MMP20 complexed with NNGH


Overview

The solution structure of the catalytic domain of MMP-20, a member of the matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid (NNGH), is here reported and compared with other MMPs-NNGH adducts. The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present structure experiences specific structural and dynamical similarities with some MMPs and differences with others, around the catalytic cavity. The present solution structure, not only contributes to fill the gap of structural knowledge on human MMPs, but also provides further information to design more selective and efficient inhibitors for a specific member of this class of proteins.

About this Structure

2JSD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase., Arendt Y, Banci L, Bertini I, Cantini F, Cozzi R, Del Conte R, Gonnelli L, FEBS Lett. 2007 Oct 2;581(24):4723-6. Epub 2007 Sep 6. PMID:17869250 Page seeded by OCA on Sun Apr 13 08:07:24 2008

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