6q84
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of RanGTP-Pdr6-eIF5A export complex== | |
| - | + | <StructureSection load='6q84' size='340' side='right'caption='[[6q84]], [[Resolution|resolution]] 3.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6q84]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q84 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q84 OCA], [http://pdbe.org/6q84 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q84 RCSB], [http://www.ebi.ac.uk/pdbsum/6q84 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q84 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KA122_YEAST KA122_YEAST]] Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR). May play a role in regulation of pleiotropic drug resistance.<ref>PMID:10525531</ref> <ref>PMID:16432237</ref> <ref>PMID:1882553</ref> <ref>PMID:18838542</ref> [[http://www.uniprot.org/uniprot/IF5A1_YEAST IF5A1_YEAST]] mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Essential for polarized growth, a process necessary for G1/S transition. May mediate large range of effects of the polyamine spermidine in the cell.<ref>PMID:10229683</ref> <ref>PMID:16157662</ref> <ref>PMID:16408210</ref> <ref>PMID:16914118</ref> <ref>PMID:19338753</ref> <ref>PMID:19424157</ref> <ref>PMID:641056</ref> <ref>PMID:8307948</ref> <ref>PMID:9582285</ref> [[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aksu, M]] | ||
| + | [[Category: Gorlich, D]] | ||
| + | [[Category: Trakhanov, S]] | ||
| + | [[Category: Vera-Rodriguez, A]] | ||
| + | [[Category: Biportin]] | ||
| + | [[Category: Importin-beta family]] | ||
| + | [[Category: Nuclear export]] | ||
| + | [[Category: Protein transport]] | ||
| + | [[Category: Translation factor]] | ||
Revision as of 08:57, 1 May 2019
Crystal structure of RanGTP-Pdr6-eIF5A export complex
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