6r7x
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)== | |
| - | + | <StructureSection load='6r7x' size='340' side='right'caption='[[6r7x]], [[Resolution|resolution]] 3.47Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6r7x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R7X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7x OCA], [http://pdbe.org/6r7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7x RCSB], [http://www.ebi.ac.uk/pdbsum/6r7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7x ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ANO10_HUMAN ANO10_HUMAN]] Adult-onset autosomal recessive cerebellar ataxia. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ANO10_HUMAN ANO10_HUMAN]] Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.<ref>PMID:20056604</ref> <ref>PMID:22946059</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
[[Category: Baronina, A]] | [[Category: Baronina, A]] | ||
| - | [[Category: | + | [[Category: Bountra, C]] |
| - | [[Category: | + | [[Category: Burgess-Brown, N A]] |
| + | [[Category: Bushell, S R]] | ||
| + | [[Category: Carpenter, E P]] | ||
[[Category: Chalk, R]] | [[Category: Chalk, R]] | ||
| + | [[Category: Chu, A]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Huiskonen, J T]] | ||
| + | [[Category: Love, J]] | ||
| + | [[Category: Mukhopadhyay, S]] | ||
| + | [[Category: Pike, A C.W]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Shintre, C A]] | ||
[[Category: Shrestha, L]] | [[Category: Shrestha, L]] | ||
| - | [[Category: Love, J]] | ||
| - | [[Category: Burgess-Brown, N.A]] | ||
| - | [[Category: Huiskonen, J.T]] | ||
| - | [[Category: Chu, A]] | ||
[[Category: Tessitore, A]] | [[Category: Tessitore, A]] | ||
| - | [[Category: | + | [[Category: Calcium activation]] |
| - | [[Category: | + | [[Category: Lipid transport]] |
| - | [[Category: | + | [[Category: Membrane protein]] |
| - | [[Category: | + | [[Category: Sgc]] |
| - | + | [[Category: Transport protein]] | |
| - | [[Category: | + | |
Revision as of 08:58, 1 May 2019
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
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Categories: Large Structures | Arrowsmith, C H | Baronina, A | Bountra, C | Burgess-Brown, N A | Bushell, S R | Carpenter, E P | Chalk, R | Chu, A | Edwards, A M | Huiskonen, J T | Love, J | Mukhopadhyay, S | Pike, A C.W | Structural genomic | Shintre, C A | Shrestha, L | Tessitore, A | Calcium activation | Lipid transport | Membrane protein | Sgc | Transport protein
