1p6t

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[[Image:1p6t.gif|left|200px]]
[[Image:1p6t.gif|left|200px]]
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{{Structure
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|PDB= 1p6t |SIZE=350|CAPTION= <scene name='initialview01'>1p6t</scene>
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The line below this paragraph, containing "STRUCTURE_1p6t", creates the "Structure Box" on the page.
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|SITE=
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4] </span>
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|GENE= YVGX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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{{STRUCTURE_1p6t| PDB=1p6t | SCENE= }}
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|RELATEDENTRY=[[1oq3|1OQ3]], [[1kqk|1KQK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6t OCA], [http://www.ebi.ac.uk/pdbsum/1p6t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p6t RCSB]</span>
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'''Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis'''
'''Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis'''
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[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: Su, X C.]]
[[Category: Su, X C.]]
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[[Category: beta-alpha-beta-beta-alpha-beta fold]]
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[[Category: Beta-alpha-beta-beta-alpha-beta fold]]
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[[Category: copa]]
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[[Category: Copa]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: p-type atpase]]
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[[Category: P-type atpase]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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[[Category: water-soluble region]]
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[[Category: Water-soluble region]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:09:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:55:42 2008''
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Revision as of 05:09, 13 April 2008

Image:1p6t.gif

Template:STRUCTURE 1p6t

Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis


Overview

The solution structure of the N-terminal region (151 amino acids) of a copper ATPase, CopA, from Bacillus subtilis, is reported here. It consists of two domains, CopAa and CopAb, linked by two amino acids. It is found that the two domains, which had already been separately characterized, interact one to the other through a hydrogen bond network and a few hydrophobic interactions, forming a single rigid body. The two metal binding sites are far from one another, and the short link between the domains prevents them from interacting. This and the surface electrostatic potential suggest that each domain receives copper from the copper chaperone, CopZ, independently and transfers it to the membrane binding site of CopA. The affinity constants of silver(I) and copper(I) are similar for the two sites as monitored by NMR. Because the present construct "domain-short link-domain" is shared also by the last two domains of the eukaryotic copper ATPases and several residues at the interface between the two domains are conserved, the conclusions of the present study have general validity for the understanding of the function of copper ATPases.

About this Structure

1P6T is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structural basis for the function of the N-terminal domain of the ATPase CopA from Bacillus subtilis., Banci L, Bertini I, Ciofi-Baffoni S, Gonnelli L, Su XC, J Biol Chem. 2003 Dec 12;278(50):50506-13. Epub 2003 Sep 27. PMID:14514665 Page seeded by OCA on Sun Apr 13 08:09:21 2008

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