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4rxf

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==Fructose-6-phosphate aldolase Y131F from E.coli==
==Fructose-6-phosphate aldolase Y131F from E.coli==
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<StructureSection load='4rxf' size='340' side='right' caption='[[4rxf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4rxf' size='340' side='right'caption='[[4rxf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rxf]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RXF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rxf]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RXF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l6w|1l6w]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l6w|1l6w]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rxf OCA], [http://pdbe.org/4rxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rxf RCSB], [http://www.ebi.ac.uk/pdbsum/4rxf PDBsum]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0825, fsa, fsaA, JW5109, mipB, ybiZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rxf OCA], [http://pdbe.org/4rxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rxf RCSB], [http://www.ebi.ac.uk/pdbsum/4rxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rxf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI]] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref>
[[http://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI]] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref>
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==See Also==
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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*[[Transaldolase|Transaldolase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Large Structures]]
[[Category: Leptihn, S]]
[[Category: Leptihn, S]]
[[Category: Samland, A K]]
[[Category: Samland, A K]]

Revision as of 10:38, 1 May 2019

Fructose-6-phosphate aldolase Y131F from E.coli

PDB ID 4rxf

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