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4rrs
From Proteopedia
(Difference between revisions)
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==8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors== | ==8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors== | ||
| - | <StructureSection load='4rrs' size='340' side='right' caption='[[4rrs]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='4rrs' size='340' side='right'caption='[[4rrs]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4rrs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4rrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RRS FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UY:(4R,4AR,10AS)-8-(2-FLUOROPYRIDIN-3-YL)-4A-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[1,3-OXAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-2-AMINE'>3UY</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3UY:(4R,4AR,10AS)-8-(2-FLUOROPYRIDIN-3-YL)-4A-METHYL-3,4,4A,10A-TETRAHYDRO-2H-SPIRO[1,3-OXAZOLE-4,10-PYRANO[3,2-B]CHROMEN]-2-AMINE'>3UY</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r5n|4r5n]], [[4rrn|4rrn]], [[4rro|4rro]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r5n|4r5n]], [[4rrn|4rrn]], [[4rro|4rro]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrs OCA], [http://pdbe.org/4rrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rrs RCSB], [http://www.ebi.ac.uk/pdbsum/4rrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rrs OCA], [http://pdbe.org/4rrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rrs RCSB], [http://www.ebi.ac.uk/pdbsum/4rrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rrs ProSAT]</span></td></tr> | ||
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==See Also== | ==See Also== | ||
| - | *[[Beta secretase|Beta secretase]] | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Brown, K D]] | [[Category: Brown, K D]] | ||
Revision as of 10:40, 1 May 2019
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors
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Categories: Human | Large Structures | Memapsin 2 | Brown, K D | Burkard, M | Cox, A A | DeLisle, R K | Do, M K.Geck | Dutcher, D | Groneberg, R | Hunt, K W | Liao, J | Liu, X | Lyssikatos, J P | Newhouse, B | Otten, J N | Purkey, H E | Rana, S | Regal, K | Rhodes, S P | Scearce-Levie, K | Siu, M | Smith, D | Thomas, A A | Vigers, G P.A | Watts, R J | Wright, A D | Aspartyl protease | Hydrolase-hydrolase inhibitor complex
