1so9

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[[Image:1so9.gif|left|200px]]
[[Image:1so9.gif|left|200px]]
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{{Structure
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|GENE= CTAG, R00908, SMC00012 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=382 Sinorhizobium meliloti])
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{{STRUCTURE_1so9| PDB=1so9 | SCENE= }}
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|RELATEDENTRY=[[1sp0|1SP0]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1so9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1so9 OCA], [http://www.ebi.ac.uk/pdbsum/1so9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1so9 RCSB]</span>
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'''Solution Structure of apoCox11, 30 structures'''
'''Solution Structure of apoCox11, 30 structures'''
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[[Category: Mangani, S.]]
[[Category: Mangani, S.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: copper protein]]
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[[Category: Copper protein]]
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[[Category: cytochrome c oxidase assembly]]
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[[Category: Cytochrome c oxidase assembly]]
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[[Category: immunoglobulin-like fold]]
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[[Category: Immunoglobulin-like fold]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:11:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:44:46 2008''
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Revision as of 05:11, 13 April 2008

Image:1so9.gif

Template:STRUCTURE 1so9

Solution Structure of apoCox11, 30 structures


Overview

Cytochrome c oxidase assembly process involves many accessory proteins including Cox11, which is a copper-binding protein required for Cu incorporation into the Cu(B) site of cytochrome c oxidase. In a genome wide search, a number of Cox11 homologs are found in all of the eukaryotes with complete genomes and in several Gram-negative bacteria. All of them possess a highly homologous soluble domain and contain an N-terminal fragment that anchors the protein to the membrane. An anchor-free construct of 164 amino acids was obtained from Sinorhizobium meliloti, and the first structure of this class of proteins is reported here. The apoform has an immunoglobulin-like fold with a novel type of beta-strand organization. The copper binding motif composed of two highly conserved cysteines is located on one side of the beta-barrel structure. The apoprotein is monomeric in the presence of dithiothreitol, whereas it dimerizes in the absence of the reductant. When copper(I) binds, NMR and extended x-ray absorption fine structure (EXAFS) data indicate a dimeric protein state with two thiolates bridging two copper(I) ions. The present results advance the knowledge on the poorly understood molecular aspects of cytochrome c oxidase assembly.

About this Structure

1SO9 is a Single protein structure of sequence from Sinorhizobium meliloti. Full crystallographic information is available from OCA.

Reference

Solution structure of Cox11, a novel type of beta-immunoglobulin-like fold involved in CuB site formation of cytochrome c oxidase., Banci L, Bertini I, Cantini F, Ciofi-Baffoni S, Gonnelli L, Mangani S, J Biol Chem. 2004 Aug 13;279(33):34833-9. Epub 2004 Jun 4. PMID:15181013 Page seeded by OCA on Sun Apr 13 08:11:09 2008

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