Sandbox Reserved 1546

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='''5H86: HUMAN GCN-5 BOUND TO BUTYRYL-COA'''=
='''5H86: HUMAN GCN-5 BOUND TO BUTYRYL-COA'''=
This project was completed by Marianne Javier, Karima MuhummadPoe, and Makayla Yang for Dr. Gluick's Spring 2019 BIOL4100K-01 class at Georgia Gwinnett College.
This project was completed by Marianne Javier, Karima MuhummadPoe, and Makayla Yang for Dr. Gluick's Spring 2019 BIOL4100K-01 class at Georgia Gwinnett College.
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'''Project Purpose:'''We chose this molecule due to its role as a histone acetyltransferase and its role in transcription regulation. It has a harder time having successful enzymatic activity if the acyl-chain is too long which is the purpose of studying the molecule. These researchers made two different acyl-CoA molecules, propionyl-CoA and butyryl-CoA. We are looking at the butyryl-CoA which has a conformation that obstructs the lysine from binding. We chose this molecule to see how Gcn5L2 chooses which acyl-chain donor to have the highest enzymatic activity.
==Function==
==Function==

Revision as of 14:04, 5 May 2019

This Sandbox is Reserved from May 28 through July 01, 2019 for use in the course Advanced Biochemistry BCHM 4100 taught by Tom Gluick at the Georgia Gwinnett College. This reservation includes Sandbox Reserved 1544 through Sandbox Reserved 1555.
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Contents

5H86: HUMAN GCN-5 BOUND TO BUTYRYL-COA

This project was completed by Marianne Javier, Karima MuhummadPoe, and Makayla Yang for Dr. Gluick's Spring 2019 BIOL4100K-01 class at Georgia Gwinnett College. Project Purpose:We chose this molecule due to its role as a histone acetyltransferase and its role in transcription regulation. It has a harder time having successful enzymatic activity if the acyl-chain is too long which is the purpose of studying the molecule. These researchers made two different acyl-CoA molecules, propionyl-CoA and butyryl-CoA. We are looking at the butyryl-CoA which has a conformation that obstructs the lysine from binding. We chose this molecule to see how Gcn5L2 chooses which acyl-chain donor to have the highest enzymatic activity.

Function

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Structural Highlights

5H86 Structure

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Relevance

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Donec non nibh hendrerit nunc blandit bibendum. Proin ultrices ex lorem, ac volutpat lorem vestibulum non. Mauris lobortis maximus nulla, a sagittis dui fringilla in. Etiam rhoncus magna a quam placerat, nec viverra urna convallis. Nulla semper ligula sodales tortor elementum molestie. Nullam tincidunt consectetur dui, nec dictum quam tempor quis. Duis ac eros a dui vestibulum feugiat eget sit amet dui.

References

Ringel, A. E., & Wolberger, C. (2016). Structural basis for acyl-group discrimination by human Gcn5L2. Acta crystallographica. Section D, Structural biology, 72(Pt 7), 841-8.

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