1szw

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[[Image:1szw.gif|left|200px]]
[[Image:1szw.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1szw |SIZE=350|CAPTION= <scene name='initialview01'>1szw</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1szw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TRUD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1szw| PDB=1szw | SCENE= }}
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|RELATEDENTRY=[[1sb7|1SB7]], [[1si7|1SI7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1szw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szw OCA], [http://www.ebi.ac.uk/pdbsum/1szw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1szw RCSB]</span>
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}}
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'''Crystal structure of E. coli tRNA pseudouridine synthase TruD'''
'''Crystal structure of E. coli tRNA pseudouridine synthase TruD'''
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[[Category: Nordlund, P.]]
[[Category: Nordlund, P.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: novel fold]]
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[[Category: Novel fold]]
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[[Category: pseudouridine synthase]]
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[[Category: Pseudouridine synthase]]
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[[Category: rna modification]]
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[[Category: Rna modification]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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[[Category: trud]]
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[[Category: Trud]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:11:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:49:12 2008''
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Revision as of 05:11, 13 April 2008

Image:1szw.gif

Template:STRUCTURE 1szw

Crystal structure of E. coli tRNA pseudouridine synthase TruD


Overview

Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine in structural RNA. The pseudouridine synthase TruD, that modifies U13 in tRNA, belongs to a recently identified and large family of pseudouridine synthases present in all kingdoms of life. We report here the crystal structure of Escherichia coli TruD at 2.0 A resolution. The structure reveals an overall V-shaped molecule with an RNA-binding cleft formed between two domains: a catalytic domain and an insertion domain. The catalytic domain has a fold similar to that of the catalytic domains of previously characterised pseudouridine synthases, whereas the insertion domain displays a novel fold.

About this Structure

1SZW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold., Ericsson UB, Nordlund P, Hallberg BM, FEBS Lett. 2004 May 7;565(1-3):59-64. PMID:15135053 Page seeded by OCA on Sun Apr 13 08:11:34 2008

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OCA

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