1ttx

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[[Image:1ttx.gif|left|200px]]
[[Image:1ttx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ttx |SIZE=350|CAPTION= <scene name='initialview01'>1ttx</scene>
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The line below this paragraph, containing "STRUCTURE_1ttx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Homo sapiens ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1ttx| PDB=1ttx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [http://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB]</span>
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}}
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'''Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy'''
'''Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy'''
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[[Category: Quattrone, A.]]
[[Category: Quattrone, A.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: ef-hand]]
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[[Category: Ef-hand]]
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[[Category: lanthanide]]
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[[Category: Lanthanide]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: oncomodulin]]
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[[Category: Oncomodulin]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:12:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:01 2008''
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Revision as of 05:12, 13 April 2008

Image:1ttx.gif

Template:STRUCTURE 1ttx

Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy


Overview

The aim of this research was to determine the structure of human beta-parvalbumin (109 amino acids) and to compare it with its paralog and ortholog proteins. The structure was determined in solution using multinuclear and multidimensional NMR methods and refined using substitution of the EF-hand Ca(2+) ion with a paramagnetic lanthanide. The resulting family of structures had a backbone rmsd of 0.50 A. Comparison with rat oncomodulin (X-ray, 1.3 A resolution) as well as with human (NMR, backbone rmsd of 0.49 A) and rat (X-ray, 2.0 A resolution) parvalbumins reveals small but reliable local differences, often but not always related to amino acid variability. The analysis of these structures has led us to propose an explanation for the different affinity for Ca(2+) between alpha- and beta-parvalbumins and between parvalbumins and calmodulins.

About this Structure

1TTX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs., Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A, Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:15610002 Page seeded by OCA on Sun Apr 13 08:12:02 2008

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