1uvq

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[[Image:1uvq.jpg|left|200px]]
[[Image:1uvq.jpg|left|200px]]
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{{Structure
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|PDB= 1uvq |SIZE=350|CAPTION= <scene name='initialview01'>1uvq</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1uvq", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:GLY+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1uvq| PDB=1uvq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uvq OCA], [http://www.ebi.ac.uk/pdbsum/1uvq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uvq RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HLA-DQ0602 IN COMPLEX WITH A HYPOCRETIN PEPTIDE'''
'''CRYSTAL STRUCTURE OF HLA-DQ0602 IN COMPLEX WITH A HYPOCRETIN PEPTIDE'''
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[[Category: Svejgaard, A.]]
[[Category: Svejgaard, A.]]
[[Category: Wyer, J R.]]
[[Category: Wyer, J R.]]
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[[Category: autoimmune disease]]
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[[Category: Autoimmune disease]]
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[[Category: diabetes]]
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[[Category: Diabetes]]
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[[Category: immunology]]
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[[Category: Immunology]]
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[[Category: mhc class ii]]
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[[Category: Mhc class ii]]
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[[Category: narcolepsy]]
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[[Category: Narcolepsy]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:12:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:15:55 2008''
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Revision as of 05:12, 13 April 2008

Image:1uvq.jpg

Template:STRUCTURE 1uvq

CRYSTAL STRUCTURE OF HLA-DQ0602 IN COMPLEX WITH A HYPOCRETIN PEPTIDE


Overview

The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying these contrasting genetic properties. Structural comparisons to homologous DQ molecules with differential disease associations highlight a previously unrecognized interplay between the volume of the P6 pocket and the specificity of the P9 pocket, which implies that presentation of an expanded peptide repertoire is critical for dominant protection against type 1 diabetes. In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role.

About this Structure

1UVQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy., Siebold C, Hansen BE, Wyer JR, Harlos K, Esnouf RE, Svejgaard A, Bell JI, Strominger JL, Jones EY, Fugger L, Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1999-2004. Epub 2004 Feb 9. PMID:14769912 Page seeded by OCA on Sun Apr 13 08:12:55 2008

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OCA

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