6hyl

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m (Protected "6hyl" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6hyl is ON HOLD
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==Structure of PCM1 LIR motif bound to GABARAP==
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<StructureSection load='6hyl' size='340' side='right'caption='[[6hyl]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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Authors: Mouilleron, S., Wirth, M., Zhang, W., O'Reilly, N., Tooze, S., Johansen, T., Razi, M., Nyoni, L., Joshi, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hyl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HYL FirstGlance]. <br>
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Description: Structure of PCM1 LIR motif bound to GABARAP
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hyl OCA], [http://pdbe.org/6hyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hyl RCSB], [http://www.ebi.ac.uk/pdbsum/6hyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hyl ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PCM1_HUMAN PCM1_HUMAN]] Differentiated thyroid carcinoma. A chromosomal aberration involving PCM1 is found in papillary thyroid carcinomas (PTCs) (PubMed:10980597). Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1 (PubMed:10980597).<ref>PMID:10980597</ref> A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma (PubMed:15805263, PubMed:16034466, PubMed:16091753, PubMed:16769584, PubMed:16424865). Translocation t(8;9)(p22;p24) with JAK2 links the protein kinase domain of JAK2 to the major portion of PCM1 (PubMed:15805263, PubMed:16034466, PubMed:16091753, PubMed:16769584, PubMed:16424865).<ref>PMID:15805263</ref> <ref>PMID:16034466</ref> <ref>PMID:16091753</ref> <ref>PMID:16424865</ref> <ref>PMID:16769584</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PCM1_HUMAN PCM1_HUMAN]] Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Involved in the biogenesis of cilia (PubMed:20551181, PubMed:24121310).<ref>PMID:12403812</ref> <ref>PMID:15659651</ref> <ref>PMID:16943179</ref> <ref>PMID:20551181</ref> <ref>PMID:24121310</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Johansen, T]]
[[Category: Joshi, D]]
[[Category: Joshi, D]]
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[[Category: Mouilleron, S]]
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[[Category: Nyoni, L]]
[[Category: Razi, M]]
[[Category: Razi, M]]
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[[Category: Johansen, T]]
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[[Category: Reilly, N O]]
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[[Category: Zhang, W]]
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[[Category: Nyoni, L]]
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[[Category: O'Reilly, N]]
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[[Category: Tooze, S]]
[[Category: Tooze, S]]
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[[Category: Mouilleron, S]]
 
[[Category: Wirth, M]]
[[Category: Wirth, M]]
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[[Category: Zhang, W]]
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[[Category: Atg8]]
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[[Category: Autophagy]]
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[[Category: Lir]]
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[[Category: Signaling protein]]

Revision as of 11:18, 10 May 2019

Structure of PCM1 LIR motif bound to GABARAP

PDB ID 6hyl

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