6hym
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of PCM1 LIR motif bound to GABARAP== | |
| - | + | <StructureSection load='6hym' size='340' side='right'caption='[[6hym]], [[Resolution|resolution]] 1.86Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hym]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HYM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hym OCA], [http://pdbe.org/6hym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hym RCSB], [http://www.ebi.ac.uk/pdbsum/6hym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hym ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/PCM1_HUMAN PCM1_HUMAN]] Differentiated thyroid carcinoma. A chromosomal aberration involving PCM1 is found in papillary thyroid carcinomas (PTCs) (PubMed:10980597). Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1 (PubMed:10980597).<ref>PMID:10980597</ref> A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma (PubMed:15805263, PubMed:16034466, PubMed:16091753, PubMed:16769584, PubMed:16424865). Translocation t(8;9)(p22;p24) with JAK2 links the protein kinase domain of JAK2 to the major portion of PCM1 (PubMed:15805263, PubMed:16034466, PubMed:16091753, PubMed:16769584, PubMed:16424865).<ref>PMID:15805263</ref> <ref>PMID:16034466</ref> <ref>PMID:16091753</ref> <ref>PMID:16424865</ref> <ref>PMID:16769584</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PCM1_HUMAN PCM1_HUMAN]] Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Involved in the biogenesis of cilia (PubMed:20551181, PubMed:24121310).<ref>PMID:12403812</ref> <ref>PMID:15659651</ref> <ref>PMID:16943179</ref> <ref>PMID:20551181</ref> <ref>PMID:24121310</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Johansen, T]] | ||
[[Category: Joshi, D]] | [[Category: Joshi, D]] | ||
| + | [[Category: Mouilleron, S]] | ||
| + | [[Category: Nyoni, L]] | ||
[[Category: Razi, M]] | [[Category: Razi, M]] | ||
| - | [[Category: | + | [[Category: Reilly, N O]] |
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Tooze, S]] | [[Category: Tooze, S]] | ||
| - | [[Category: Mouilleron, S]] | ||
[[Category: Wirth, M]] | [[Category: Wirth, M]] | ||
| + | [[Category: Zhang, W]] | ||
| + | [[Category: Atg8]] | ||
| + | [[Category: Autophagy]] | ||
| + | [[Category: Lir]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 11:19, 10 May 2019
Structure of PCM1 LIR motif bound to GABARAP
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Categories: Large Structures | Johansen, T | Joshi, D | Mouilleron, S | Nyoni, L | Razi, M | Reilly, N O | Tooze, S | Wirth, M | Zhang, W | Atg8 | Autophagy | Lir | Signaling protein
