6nnq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6nnq is ON HOLD until Paper Publication
+
==Non-covalent structure of SENP1 in complex with SUMO2==
-
 
+
<StructureSection load='6nnq' size='340' side='right'caption='[[6nnq]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
-
Authors: Ambaye, N.D.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6nnq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NNQ FirstGlance]. <br>
-
Description: Non-covalent structure of SENP1 in complex with SUMO2
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nnq OCA], [http://pdbe.org/6nnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nnq RCSB], [http://www.ebi.ac.uk/pdbsum/6nnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nnq ProSAT]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
-
[[Category: Ambaye, N.D]]
+
== Function ==
 +
[[http://www.uniprot.org/uniprot/SENP1_HUMAN SENP1_HUMAN]] Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.<ref>PMID:10652325</ref> <ref>PMID:15199155</ref> <ref>PMID:16253240</ref> <ref>PMID:16553580</ref> [[http://www.uniprot.org/uniprot/SUMO3_HUMAN SUMO3_HUMAN]] Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.<ref>PMID:11451954</ref> <ref>PMID:18538659</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Ambaye, N D]]
 +
[[Category: Hydrolase-protein binding complex]]
 +
[[Category: Senp1]]
 +
[[Category: Sumo2]]
 +
[[Category: Sumoylation]]

Revision as of 11:22, 10 May 2019

Non-covalent structure of SENP1 in complex with SUMO2

PDB ID 6nnq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6nnq"
Personal tools