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6e7d

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==Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b==
==Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b==
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<StructureSection load='6e7d' size='340' side='right' caption='[[6e7d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='6e7d' size='340' side='right'caption='[[6e7d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e7d]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E7D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e7d]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E7D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Clec2d, Clrb, Ocil ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Klrb1b, Klrb1d, Ly55d, Nkrp1b, Nkrp1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7d OCA], [http://pdbe.org/6e7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e7d RCSB], [http://www.ebi.ac.uk/pdbsum/6e7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7d OCA], [http://pdbe.org/6e7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e7d RCSB], [http://www.ebi.ac.uk/pdbsum/6e7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLC2D_MOUSE CLC2D_MOUSE]] Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).<ref>PMID:11278931</ref> <ref>PMID:12374791</ref> <ref>PMID:14990792</ref> <ref>PMID:15123656</ref> <ref>PMID:16751398</ref> [[http://www.uniprot.org/uniprot/KRBBB_MOUSE KRBBB_MOUSE]] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.<ref>PMID:12858173</ref> <ref>PMID:14990792</ref>
[[http://www.uniprot.org/uniprot/CLC2D_MOUSE CLC2D_MOUSE]] Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).<ref>PMID:11278931</ref> <ref>PMID:12374791</ref> <ref>PMID:14990792</ref> <ref>PMID:15123656</ref> <ref>PMID:16751398</ref> [[http://www.uniprot.org/uniprot/KRBBB_MOUSE KRBBB_MOUSE]] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.<ref>PMID:12858173</ref> <ref>PMID:14990792</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The interaction between natural killer (NK) cell inhibitory receptors and their cognate ligands constitutes a key mechanism by which healthy tissues are protected from NK cell-mediated lysis. However, self-ligand recognition remains poorly understood within the prototypical NKR-P1 receptor family. Here we report the structure of the inhibitory NKR-P1B receptor bound to its cognate host ligand, Clr-b. NKR-P1B and Clr-b interact via a head-to-head docking mode through an interface that includes a large array of polar interactions. NKR-P1B:Clr-b recognition is extremely sensitive to mutations at the heterodimeric interface, with most mutations severely impacting both Clr-b binding and NKR-P1B receptor function to implicate a low affinity interaction. Within the structure, two NKR-P1B:Clr-b complexes are cross-linked by a non-classic NKR-P1B homodimer, and the disruption of homodimer formation abrogates Clr-b recognition. These data provide an insight into a fundamental missing-self recognition system and suggest an avidity-based mechanism underpins NKR-P1B receptor function.
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Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition.,Balaji GR, Aguilar OA, Tanaka M, Shingu-Vazquez MA, Fu Z, Gully BS, Lanier LL, Carlyle JR, Rossjohn J, Berry R Nat Commun. 2018 Nov 5;9(1):4623. doi: 10.1038/s41467-018-06989-2. PMID:30397201<ref>PMID:30397201</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6e7d" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
[[Category: Balaji, G R]]
[[Category: Balaji, G R]]
[[Category: Berry, R]]
[[Category: Berry, R]]

Revision as of 13:23, 10 May 2019

Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b

PDB ID 6e7d

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