We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Clp Protease

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 12: Line 12:
CLP is a heterodimer containing an ATP-binding regulatory subunit A '''ClpA''' or Hsp100 in [[Heat Shock Proteins]] and catalytic subunit P '''ClpP'''. The proteolytic complex is composed of <scene name='50/508398/Cv/2'>2 heptameric rings of ClpP</scene> flanked by hexameric rings of ClpA. For full proteolytic activity ClpP must associate with one of two related ATPase subunits: ClpA and [[ClpX]].
CLP is a heterodimer containing an ATP-binding regulatory subunit A '''ClpA''' or Hsp100 in [[Heat Shock Proteins]] and catalytic subunit P '''ClpP'''. The proteolytic complex is composed of <scene name='50/508398/Cv/2'>2 heptameric rings of ClpP</scene> flanked by hexameric rings of ClpA. For full proteolytic activity ClpP must associate with one of two related ATPase subunits: ClpA and [[ClpX]].
-
</StructureSection>
+
 
==3D structures of Clp protease==
==3D structures of Clp protease==
 +
[[Clp protease 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*CLP P subunit
+
-
 
+
-
**[[1tyf]], [[1yg6]] – EcCLP – ''Escherichia coli''<br />
+
-
**[[1yg8]], [[3hln]] - EcCLP (mutant)<br />
+
-
**[[2ds6]] - EcCLP Zinc-binding domain<br />
+
-
**[[1y7o]] – CLP – ''Streptococcus pneumoniae''<br />
+
-
**[[1tg6]] - CLP – human<br />
+
-
**[[2f6i]], [[4gm2]], [[4hnk]] - CLP – ''Plasmodium falciparum''<br />
+
-
**[[2cby]], [[2ce3]], [[2c8t]], [[4u0h]], [[5e0s]], [[5dzk]] - MtCLP – ''Mycobacterium tuberculosis''<br />
+
-
**[[3fes]] - CLP – ''Clostridium difficile''<br />
+
-
**[[3ktg]], [[3kth]], [[3tt6]] – BsCLP – ''Bacillus subtilis''<br />
+
-
**[[3p2l]], [[5g1s]], [[5g1r]], [[5g1q]] - CLP – ''Francisella tulerensis''<br />
+
-
**[[3q7h]] - CLP – ''Coxiella burnetii''<br />
+
-
**[[3qwd]], [[3st9]], [[3sta]], [[3v5e]], [[4emm]], [[4mxi]] - SaCLP – ''Staphylococcus aureus''<br />
+
-
**[[3v5i]], [[4emp]], [[5c90]] - SaCLP (mutant)<br />
+
-
**[[2zl0]] - HpCLP – ''Helicobacter pylori''<br />
+
-
**[[2zl3]] - HpCLP (mutant)<br />
+
-
**[[4jcq]], [[4jct]], [[4ryf]] – LmCLP – ''Listeria monocytogenes''<br />
+
-
**[[4jcr]] - LmCLP (mutant)<br />
+
-
 
+
-
*''CLP P subunit complex''
+
-
 
+
-
**[[2fzs]], [[3mt6]] - EcCLP + peptide<br />
+
-
**[[2zl2]] - HpCLP + peptide<br />
+
-
**[[2zl4]] - HpCLP (mutant) + peptide<br />
+
-
**[[3kti]], [[3ktj]], [[3ktk]] - BsCLP + peptide<br />
+
-
**[[3tt7]] - BsCLP + DFP<br />
+
-
**[[4u0g]] – MtCLP + ADEP + agonist<br />
+
-
**[[5dl1]] – SaCLP + inhibitor<br />
+
-
**[[5dkp]] – CLP + ADEP – ''Neisseria meningitidis''<br />
+
-
 
+
-
*CLP A subunit and CLP N see [[Heat Shock Proteins]] Hsp100
+
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 06:42, 14 May 2019

E. coli Clp protease catalytic subunit (PDB entry 1tyf)

Drag the structure with the mouse to rotate


References

  1. ↑ Maurizi MR, Clark WP, Katayama Y, Rudikoff S, Pumphrey J, Bowers B, Gottesman S. Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli. J Biol Chem. 1990 Jul 25;265(21):12536-45. PMID:2197275

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Clp_Protease"
Personal tools