Complement C3

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</StructureSection>
</StructureSection>
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==3D structures of complement C3==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Complement C3
 
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**[[2a73]] – hCC3 – human <br />
 
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**[[1ghq]] – hCC3 residues 996-1300 + Epstein-Barr virus receptor <br />
 
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**[[4zh1]] – hCC3 + complement factor H <br />
 
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**[[2b39]] – bCC3 – bovine <br />
 
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*Complement C3a (anaphylatoxin)
 
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**[[4hw5]], [[4hwj]], [[4i6o]] – hCC3 <br />
 
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*Complement C3b
 
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**[[2i07]], [[5fo7]] – hCC3 β+α’ chains<br />
 
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**[[5fob]] – hCC3 β+α’ chains + inhibitor<br />
 
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**[[5fo9]] – hCC3 β+α’ chains + protein<br />
 
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**[[5foa]], [[5f08]], [[2icf]], [[2wii]] – hCC3 α+β chains + protein <br />
 
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**[[3g6j]], [[6ehg]] – hCC3 α+β chains + antibody<br />
 
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**[[5o35]] – hCC3 α chain + complement factor H<br />
 
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**[[5o32]] – hCC3 α chain + complement factor I<br />
 
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**[[2xwb]] – hCC3 α+β chains + complement factor B + complement factor D<br />
 
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**[[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />
 
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**[[5nbq]] – hCC3 α chain + complement factor B <br />
 
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**[[5fo8]] – hCC3 α chain + membrane cofactor protein<br />
 
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**[[5m6w]] – hCC3 α+β chains + complement factor H + complement inhibitor<br />
 
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**[[3l5n]], [[3ohx]] – hCC3 α+β chains + protein inhibitor<br />
 
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**[[2win]] – hCC3 α+β chains + complement factor B BB fragment + protein inhibitor<br />
 
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*Complement C3c
 
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**[[2a74]] – hCC3 <br />
 
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**[[2qki]] – hCC3 + compstatin <br />
 
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**[[3l3o]], [[3nms]] – hCC3 + staphylococcal complement inhibitor<br />
 
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**[[2ice]] – hCC3 α+β chains + protein CRIG<br />
 
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**[[3t4a]] – hCC3 α+β chains + fibrinogen-binding protein <br />
 
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*Complement C3d
 
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**[[5fcr]] – CC3 - mouse <br />
 
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**[[1c3d]] – hCC3 (mutant) <br />
 
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**[[1w2s]], [[3oed]] – hCC3 1-2 sushi domains + complement receptor type 2 precursor<br />
 
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**[[2gox]], [[3d5r]], [[3d5s]] – hCC3 α chain fragment + fibrinogen-binding protein <br />
 
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**[[2noj]] – hCC3 α chain fragment (mutant) + EFB homologous protein <br />
 
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**[[2wy7]], [[2wy8]] – hCC3 α chain fragment (mutant) + IGG-binding protein <br />
 
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**[[3oxu]] – hCC3 α chain fragment (mutant) + HF protein <br />
 
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**[[4m76]] – hCC3 α chain fragment (mutant) + integrin α-M <br />
 
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**[[2xqw]] – hCC3 + complement factor H 19-20 sushi domains<br />
 
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**[[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />
 
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**[[5mt0]], [[5mt4]], [[5tca]], [[5tcc]], [[5fbe]], [[5fbi]], [[5fck]] – hCC3 + inhibitor<br />
 
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**[[1qqf]] – rCC3 G fragment - rat <br />
 
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**[[1qsj]] – rCC3 G fragment (mutant) <br />
 
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}}
 
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== References ==
== References ==

Revision as of 10:15, 14 May 2019

Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG (cyan) and Ca+2 ion (green) (PDB code 2icf).

Drag the structure with the mouse to rotate

References

  1. ↑ Sahu A, Lambris JD. Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol Rev. 2001 Apr;180:35-48. PMID:11414361
  2. ↑ Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M. Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature. 2006 Nov 9;444(7116):217-20. Epub 2006 Oct 15. PMID:17051150 doi:10.1038/nature05263

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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