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Haptoglobin receptor
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
'''Haptoglobin receptor''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]]. | '''Haptoglobin receptor''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]]. | ||
| - | *<scene name='70/706235/Cv/ | + | *<scene name='70/706235/Cv/5'>IsdH NEAT-3 domain complex with heme-containing hemoglobin subunits α and β</scene>. (PDB code [[3szk]]) |
| - | *<scene name='70/706235/Cv/ | + | *<scene name='70/706235/Cv/6'>Heme binding in subunit α</scene>. |
| - | *<scene name='70/706235/Cv/ | + | *<scene name='70/706235/Cv/7'>Heme binding in subunit β</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 13:06, 14 May 2019
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3D Structures of haptoglobin receptor
Updated on 14-May-2019
References
- ↑ Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E. A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296. PMID:18451305 doi:http://dx.doi.org/10.1126/science.1156296
