Hemagglutinin-esterase

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Revision as of 13:12, 15 May 2019

Pig torovirus glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate 3i1l

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Updated on 15-May-2019

↑ de Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8
↑ Langereis MA, Zeng Q, Heesters BA, Huizinga EG, de Groot RJ. The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture. PLoS Pathog. 2012 Jan;8(1):e1002492. doi: 10.1371/journal.ppat.1002492. Epub 2012, Jan 26. PMID:22291594 doi:http://dx.doi.org/10.1371/journal.ppat.1002492

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 == Structural highlights ==
-The biological assmebly of HE is a <scene name='48/484851/Cv/2'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/3'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/5'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/6'>conserved metal-binding site</scene><ref>PMID:22291594</ref>.
+The biological assmebly of HE is a <scene name='48/484851/Cv/7'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/8'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/9'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/10'>conserved metal-binding site</scene><ref>PMID:22291594</ref>.
 </StructureSection>
 ==3D structures of hemagglutinin-esterase==