User:Eliška Koutná/Sandbox 3

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Revision as of 14:49, 15 May 2019

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 == '''Protein structure''' ==
-The PrPSc differs from PrPC solely in conformation and is its isoform. The mature PrPC consists of approx. 208 amino acids, arranged as a disordered N-terminus and a globular C-terminal domain consisting of three α-helices and a short, antiparallel β-pleated sheet. <ref>DOI 10.1038/382180a0</ref> <ref>DOI 10.1073/pnas.97.1.145</ref>. There is a GPI membrane anchor at the C-terminus that tethers the protein to cell membranes and proteins that are secreted and lacking the anchor component has been proven to be unaffected by the infectious isoform <ref>DOI 10.1126/science.1110837</ref>. In contrast to the natural form of prion protein with only about 3 % of β-sheet secondary structure, the PrPSc form has about 47 % of the secondary structure in β-sheets <ref name="pan">DOI 10.1073/pnas.90.23.10962</ref>
+The PrPSc differs from PrPC solely in conformation and is its isoform. The mature PrPC consists of approx. 208 amino acids, arranged as a disordered N-terminus and a globular C-terminal domain consisting of three α-helices and a short, antiparallel β-pleated sheet. <ref>DOI 10.1038/382180a0</ref> <ref>DOI 10.1073/pnas.97.1.145</ref>.
 == References ==
 <references/>